Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder
clinically characterized by cognitive impairment, abnormal behavior, and social deficits …

Stromal interaction molecules (STIMs), including STIM1 and STIM2, are single-pass
transmembrane proteins that are located predominantly in the endoplasmic reticulum (ER) …

Dysregulation in calcium signaling pathways plays a major role in the initiation of
Alzheimer's disease (AD) pathogenesis. Accumulative experimental evidence obtained with …

Highlights•Lack of a cure for AD has prompted the exploration of novel therapeutic
approaches.•CRISPR-Cas9 could be a tool for AD therapeutics by correcting faulty …

Although the physiological role of the full-length Amyloid Precursor Protein (APP) and its
proteolytic fragments remains unclear, they are definitively crucial for normal synaptic …

Background: COVID-19 pandemic is a global crisis which results in millions of deaths and
causes long-term neurological sequelae, such as Alzheimer's disease (AD). Objective: We …

DNA damage represents a challenge for cells, as this damage must be eliminated to
preserve cell viability and the transmission of genetic information. To reduce or eliminate …

Located at the level of the endoplasmic reticulum (ER) membrane, stromal interacting
molecule 1 (STIM1) undergoes a complex conformational rearrangement after depletion of …

Background Tobacco is a risk factor for oral squamous cell carcinoma (OSCC). Some cases
of OSCC occur without any known cause and is called idiopathic OSCC. Understanding …

基质互作分子1 (stromal interaction molecule 1, STIM1) 是细胞钙库操纵性钙内流(store-
operated calcium entry, SOCE) 通路的关键成员, 它定位在内质网膜上, 并在多种肿瘤细胞中高 …