Converging evidence continues to point towards Tau aggregation and pathology formation
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …

Tau is well established as a microtubule-associated protein in neurons. However, under
pathological conditions, aberrant assembly of tau into insoluble aggregates is accompanied …

Assembly of microtubule-associated protein tau into filamentous inclusions underlies a
range of neurodegenerative diseases. Tau filaments adopt different conformations in …

Tauopathies consist of over 25 different neurodegenerative diseases that include
argyrophilic grain disease (AGD), progressive supranuclear palsy (PSP), corticobasal …

Heparin has been recognized as a valuable anticoagulant and antithrombotic for several
decades and is still widely used in clinical practice for a variety of indications. The …

Tau is the major microtubule associated protein (MAP) of a mature neuron. The other two
neuronal MAPs are MAP1 and MAP2. An established function of MAPs is their interaction …

Tau is a microtubule-associated protein with versatile functions in the dynamic assembly of
the neuronal cytoskeleton. Four-repeat (4R-) tauopathies are a group of neurodegenerative …

Glycosaminoglycans (GAGs) are important complex carbohydrates that participate in many
biological processes through the regulation of their various protein partners. Biochemical …

Alzheimer disease is characterized by abnormal protein deposits in the brain, such as
extracellular amyloid plaques and intracellular neurofibrillary tangles. The tangles are made …

Alzheimer disease (AD) and related tauopathies are histopathologically characterized by a
specific type of slow and progressive neurodegeneration, which involves the abnormal …