A systematic review of the valproic-acid-induced rodent model of autism

D Chaliha, M Albrecht, M Vaccarezza… - Developmental …, 2020 - karger.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterised by
repetitive behaviours, cognitive rigidity/inflexibility, and social-affective impairment …

Prenatal valproate in rodents as a tool to understand the neural underpinnings of social dysfunctions in autism spectrum disorder

AM Tartaglione, S Schiavi, G Calamandrei, V Trezza - Neuropharmacology, 2019 - Elsevier
Impairments in social interaction and verbal and non verbal communication are among the
main features of Autism Spectrum Disorder (ASD). The causes of ASD are still unknown but …

Valproic acid exposure impairs ultrasonic communication in infant, adolescent and adult rats

K Gzielo, A Potasiewicz, M Hołuj, E Litwa… - European …, 2020 - Elsevier
Persistent deficits of social communication are a hallmark of autism spectrum disorders
(ASD). Communication disabilities can be experimentally modeled using rodents' ultrasonic …

Impaired repair of DNA damage is associated with autistic-like traits in rats prenatally exposed to valproic acid

M Servadio, A Manduca, F Melancia, L Leboffe… - European …, 2018 - Elsevier
Prenatal exposure to the antiepileptic and mood stabilizer valproic acid (VPA) is an
environmental risk factor for autism spectrum disorders (ASD), although recent …

Chronic Ambient Ozone Exposure Aggravates Autism-Like Symptoms in a Susceptible Mouse Model

W Ling, Z Ren, W Wang, D Lu, Q Zhou… - Environmental …, 2023 - ACS Publications
Although there is evidence that exposure to ground-level ozone (O3) may cause an
increased risk of neurological disorders (eg, autistic spectrum disorder), low-dose chronic …

The Notch1/Hes1 signaling pathway affects autophagy by adjusting DNA methyltransferases expression in a valproic acid-induced autism spectrum disorder model

Y Li, L Ma, Y Deng, Z Du, B Guo, J Yue, X Liu… - …, 2023 - Elsevier
As a pervasive neurodevelopmental disease, autism spectrum disorder (ASD) is caused by
both hereditary and environmental elements. Research has demonstrated the functions of …

Effects of PM2.5 and gases exposure during prenatal and early-life on autism–like phenotypes in male rat offspring

B Emam, A Shahsavani, F Khodagholi… - Particle and fibre …, 2020 - Springer
Background Epidemiological studies have reported associations between elevated air
pollution and autism spectrum disorders (ASD). However, we hypothesized that exposure to …

Strain differences in the susceptibility to the gut–brain axis and neurobehavioural alterations induced by maternal immune activation in mice

LH Morais, D Felice, AV Golubeva… - Behavioural …, 2018 - journals.lww.com
There is a growing realization that the severity of the core symptoms of autism spectrum
disorders and schizophrenia is associated with gastrointestinal dysfunction. Nonetheless …

Consequences of prenatal exposure to valproic acid in the socially monogamous prairie voles

L Sailer, F Duclot, Z Wang, M Kabbaj - Scientific reports, 2019 - nature.com
Environmental risk factors contribute to autism spectrum disorders (ASD) etiology. In
particular, prenatal exposure to the highly teratogenic anticonvulsant valproic acid (VPA) …

Prenatal alcohol exposure disrupts male adolescent social behavior and oxytocin receptor binding in rodents

PJ Holman, L Ellis, E Morgan, J Weinberg - Hormones and Behavior, 2018 - Elsevier
Social behavior deficits resulting from prenatal alcohol exposure (PAE) emerge early in life
and become more pronounced across development. Maturational changes associated with …