Many studies of chemopreventive drugs have suggested that their beneficial effects on
suppression of carcinogenesis and many other chronic diseases are mediated through …

Background Diabetes has emerged as a major threat to health worldwide. Scope of Review
The exact mechanisms underlying the disease are unknown; however, there is growing …

K elch‐like ECH‐associated protein 1 (K eap1)‐nuclear factor erythroid 2‐related factor 2 (N
rf2)‐antioxidant response elements (ARE) pathway represents one of the most important …

Peripheral neuropathy is a severe dose limiting toxicity associated with cancer
chemotherapy. Ever since it was identified, the clear pathological mechanisms underlying …

Type 2 diabetes mellitus (DM) has reached pandemic proportions and effective prevention
strategies are wanted. Its onset is accompanied by cellular distress, the nuclear factor …

We review the rationale for the use of synthetic oleanane triterpenoids (SOs) for prevention
and treatment of disease, as well as extensive biological data on this topic resulting from …

Parkinson's disease (PD) is the second most common age-related neurodegenerative
disorder typified by tremor, rigidity, akinesia and postural instability due in part to the loss of …

High glucose driven reactive oxygen intermediates production and inflammatory damage
are recognized contributors of nerve dysfunction and subsequent damage in diabetic …

Oxidative stress, involved in many diseases, is defined as an impaired balance between
reactive oxygen species (ROS) production and antioxidant defences. Antioxidant enzymes …

Rutin exhibits antidiabetic, antioxidant and anti-inflammatory properties, which makes rutin
an attractive candidate for diabetic complications. The present study was designed to …