Cellular growth, function, and protection require proper iron management, and ferritin plays
a crucial role as the major iron sequestration and storage protein. Ferritin is a 24 subunit …

New insights into the field of iron metabolism within the tumor microenvironment have been
uncovered in recent years. Iron promotes the production of reactive oxygen species, which …

Abstract" Serum ferritin" presents a paradox, as the iron storage protein ferritin is not
synthesised in serum yet is to be found there. Serum ferritin is also a well known …

Site-specific Fe 2+ generation is promising for tumor therapy. Up to now, reported materials
or systems for Fe 2+ delivery do not naturally exist in the body, and their biological safety …

Abstract Hydrogen peroxide (H 2 O 2) is unique among general toxins, because it is stable
in abiotic environments at ambient temperature and neutral pH, yet rapidly kills any type of …

Iron (Fe) species play a number of biologically and pathologically important roles. In
particular, iron is a key element in oxygen sensing in living tissue where its metabolism is …

Ferritins, the main intracellular iron storage proteins, have been studied for over 60 years,
mainly focusing on the mammalian ones. This allowed the elucidation of the structure of …

This review discusses the chemical mechanisms of ascorbate-dependent reduction and
solubilization of ferritin's ferric iron core and subsequent release of ferrous iron. The process …

Ferritins are highly conserved supramolecular protein nanostructures composed of two
different subunit types, H (heavy) and L (light). The two subunits co-assemble into a 24 …

Ferritinophagy is the process of autophagic degradation of ferritin that participates in the
regulation of cellular iron homeostasis. This process was shown to be mediated by the …