Cancer has long been a grievous disease complicated by innumerable players aggravating
its cure. Many clinical studies demonstrated the prognostic relevance of the tumor …

Gallstone disease is a common pathology of the digestive system with nearly a 10–20%
incidence rate among adults. The mainstay of treatment is cholecystectomy, which is …

Medicinal chemistry is still clearly dominated by organic chemistry. Most of the marketed
drugs are purely organic molecules. The right-hand neighbors of carbon in the periodic …

We demonstrate a computational network model that integrates 18 in vitro, high-throughput
screening assays measuring estrogen receptor (ER) binding, dimerization, chromatin …

Drugs, their targets and the nature and number of drug targets | Nature Reviews Drug Discovery
Skip to main content Thank you for visiting nature.com. You are using a browser version with …

Neuroimaging and postmortem studies of subjects with major depressive disorder (MDD)
reveal smaller hippocampal volume with lengthening duration of illness. Pathology in …

The estrogen receptor (ER) mediates most of the biological effects of estrogens at the level
of gene regulation by interacting through its site‐specific DNA and with other coregulatory …

The phytoecdysteroids (PEs) comprise a large group of biologically-active plant steroids,
which have structures similar to those of insect-molting hormones. PEs are distributed in …

Estrogen influences the physiology of many target tissues in both women and men. The long-
term effects of estrogen are mediated predominantly by nuclear estrogen receptors (ERs) …

1Fishberg Department of Neuroscience, Kastor Neurobiology of Aging Laboratories, and
Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New …