Responses of microorganisms to osmotic stress
E Bremer, R Krämer - Annual review of Microbiology, 2019 - annualreviews.org
The cytoplasm of bacterial cells is a highly crowded cellular compartment that possesses
considerable osmotic potential. As a result, and owing to the semipermeable nature of the …
considerable osmotic potential. As a result, and owing to the semipermeable nature of the …
Cyclic di-AMP signaling in bacteria
J Stülke, L Krüger - Annual review of microbiology, 2020 - annualreviews.org
The second messenger molecule cyclic di-AMP (c-di-AMP) is formed by many bacteria and
archaea. In many species that produce c-di-AMP, this second messenger is essential for …
archaea. In many species that produce c-di-AMP, this second messenger is essential for …
Making and breaking of an essential poison: the cyclases and phosphodiesterases that produce and degrade the essential second messenger cyclic di-AMP in …
FM Commichau, JL Heidemann, R Ficner… - Journal of …, 2019 - Am Soc Microbiol
Cyclic di-AMP is a second-messenger nucleotide that is produced by many bacteria and
some archaea. Recent work has shown that c-di-AMP is unique among the signaling …
some archaea. Recent work has shown that c-di-AMP is unique among the signaling …
Cyclic di-AMP, a second messenger of primary importance: tertiary structures and binding mechanisms
J He, W Yin, MY Galperin, SH Chou - Nucleic acids research, 2020 - academic.oup.com
Cyclic diadenylate (c-di-AMP) is a widespread second messenger in bacteria and archaea
that is involved in the maintenance of osmotic pressure, response to DNA damage, and …
that is involved in the maintenance of osmotic pressure, response to DNA damage, and …
Purine nucleosides interfere with c-di-AMP levels and act as adjuvants to re-sensitize MRSA to β-lactam antibiotics
AC Nolan, MS Zeden, I Kviatkovski, C Campbell… - Mbio, 2023 - Am Soc Microbiol
The purine-derived signaling molecules c-di-AMP and (p) ppGpp control mecA/PBP2a-
mediated β-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA) raise …
mediated β-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA) raise …
c-di-AMP signaling is required for bile salt resistance, osmotolerance, and long-term host colonization by Clostridioides difficile
M Oberkampf, A Hamiot, P Altamirano-Silva… - Science …, 2022 - science.org
To colonize the host and cause disease, the human enteropathogen Clostridioides difficile
must sense, respond, and adapt to the harsh environment of the gastrointestinal tract. We …
must sense, respond, and adapt to the harsh environment of the gastrointestinal tract. We …
[HTML][HTML] Metabolic reprogramming and altered cell envelope characteristics in a pentose phosphate pathway mutant increases MRSA resistance to β-lactam …
Central metabolic pathways control virulence and antibiotic resistance, and constitute
potential targets for antibacterial drugs. In Staphylococcus aureus the role of the pentose …
potential targets for antibacterial drugs. In Staphylococcus aureus the role of the pentose …
The ever-expanding world of bacterial cyclic oligonucleotide second messengers
S hun Yoon, CM Waters - Current opinion in microbiology, 2021 - Elsevier
Highlights•Cyclic dinucleotide and trinucleotide second messengers are utilized by bacteria
to sense and adapt to their environment.•3′–5′, 3′–5′ cyclic di-GMP regulates …
to sense and adapt to their environment.•3′–5′, 3′–5′ cyclic di-GMP regulates …
Gating by ionic strength and safety check by cyclic-di-AMP in the ABC transporter OpuA
HR Sikkema, M van den Noort, J Rheinberger… - Science …, 2020 - science.org
(Micro) organisms are exposed to fluctuating environmental conditions, and adaptation to
stress is essential for survival. Increased osmolality (hypertonicity) causes outflow of water …
stress is essential for survival. Increased osmolality (hypertonicity) causes outflow of water …
[HTML][HTML] Sustained sensing in potassium homeostasis: cyclic di-AMP controls potassium uptake by KimA at the levels of expression and activity
J Gundlach, L Krüger, C Herzberg, A Turdiev… - Journal of Biological …, 2019 - ASBMB
The signaling nucleotide cyclic di-AMP (c-di-AMP) is the only known essential second
messenger in bacteria. Recently, c-di-AMP has been identified as being essential for …
messenger in bacteria. Recently, c-di-AMP has been identified as being essential for …