Physiological and pathophysiological bone turnover—role of the immune system

MN Weitzmann, I Ofotokun - Nature Reviews Endocrinology, 2016 - nature.com
Osteoporosis develops when the rate of osteoclastic bone breakdown (resorption) exceeds
that of osteoblastic bone formation, which leads to loss of BMD and deterioration of bone …

A review of long-term toxicity of antiretroviral treatment regimens and implications for an aging population

A Chawla, C Wang, C Patton, M Murray… - Infectious diseases and …, 2018 - Springer
Human immunodeficiency virus (HIV) is a chronic infectious disease currently requiring
lifelong antiretroviral therapy (ART). People living with HIV (PLWH) face an increased risk of …

Bone and the immune system

MN Weitzmann - Bone Toxicology, 2017 - Springer
The mechanisms that control physiological and pathological bone mass and turnover have
been extensively investigated over the past several decades. One surprising discovery that …

Worldwide relative smoking prevalence among people living with and without HIV

PI Johnston, SW Wright, M Orr, FA Pearce, JW Stevens… - Aids, 2021 - journals.lww.com
Objective and design: People living with HIV (PLH) suffer disproportionately from the chronic
diseases exacerbated by smoking tobacco. We performed a systematic review and meta …

Dysregulated B cell expression of RANKL and OPG correlates with loss of bone mineral density in HIV infection

K Titanji, A Vunnava, AN Sheth, C Delille… - PLoS …, 2014 - journals.plos.org
HIV infection is associated with high rates of osteopenia and osteoporosis, but the
mechanisms involved are unclear. We recently reported that bone loss in the HIV transgenic …

Antiretrovirals, fractures, and osteonecrosis in a large international HIV cohort

ÁH Borges, J Hoy, E Florence… - Clinical Infectious …, 2017 - academic.oup.com
Abstract Background. Antiretrovirals (ARVs) affect bone density and turnover, but their effect
on risk of fractures and osteonecrosis of the femoral head is less understood. We …

HIV infection and bone disease

J Compston - Journal of internal medicine, 2016 - Wiley Online Library
The success of antiretroviral therapy in treating HIV infection has greatly prolonged life
expectancy in affected individuals, transforming the disease into a chronic condition. A …

British HIV Association guidelines for the treatment of HIV-1-positive adults with antiretroviral therapy 2015

D Churchill, L Waters, N Ahmed, B Angus… - HIV …, 2016 - discovery.ucl.ac.uk
The overall purpose of these guidelines is to provide guidance on best clinical practice in
the treatment and management of adults with HIV infection on antiretroviral therapy (ART) …

Infection after fracture osteosynthesis–part I: pathogenesis, diagnosis and classification

C Fang, TM Wong, TW Lau, KKW To… - Journal of …, 2017 - journals.sagepub.com
Bone and surgical site infections after osteosynthesis are notoriously difficult to manage and
pose a tremendous burden in fracture management. In this article, we use the term …

Secondary osteoporosis: pathophysiology & diagnosis

GR Emkey, S Epstein - Best practice & research Clinical endocrinology & …, 2014 - Elsevier
Osteoporosis is a skeletal disease characterized by decreased bone mass and
microarchitectural changes in bone tissue that increase the susceptibility to fracture …