Theranostic fluorescent probes

A Sharma, P Verwilst, M Li, D Ma, N Singh… - Chemical …, 2024 - ACS Publications
The ability to gain spatiotemporal information, and in some cases achieve spatiotemporal
control, in the context of drug delivery makes theranostic fluorescent probes an attractive …

Recent advances in organelle-targeted organic photosensitizers for efficient photodynamic therapy

M Dirak, CM Yenici, S Kolemen - Coordination Chemistry Reviews, 2024 - Elsevier
Photodynamic therapy (PDT) is a long known, FDA approved, and highly promising
therapeutic modality, which is still developing. Photosensitizers (PSs) are at the core of PDT …

A first-in-class β-glucuronidase responsive conjugate for selective dual targeted and photodynamic therapy of bladder cancer

VF Otvagin, LV Krylova, NN Peskova… - European Journal of …, 2024 - Elsevier
In this report, we present a novel prodrug strategy that can significantly improve the
efficiency and selectivity of combined therapy for bladder cancer. Our approach involved the …

Developing Chlorin/Arylaminoquinazoline Conjugates with Nanomolar Activity for Targeted Photodynamic Therapy: Design, Synthesis, SAR, and Biological …

LV Krylova, VF Otvagin, GP Gribova… - Journal of Medicinal …, 2024 - ACS Publications
In this report, we developed novel chlorin/arylaminoquinazoline conjugates for targeted
photodynamic therapy of cancer. The synthesized photosensitizers consisted of chlorin-e 6 …

Modular Design and Scaffold‐Synthesis of Multi‐Functional Fluorophores for Targeted Cellular Imaging and Pyroptosis

L Zhang, C Wang, Y Li, H Wang, K Sun… - Angewandte Chemie …, 2025 - Wiley Online Library
Fluorophores are essential tools for optical imaging and biomedical research. Their
synthetic modification to incorporate new functions, however, remains a challenging task …

pH-Sensitive and Lysosome Targetable Photosensitizers Based on BODIPYs

X Liu, S Yu, Y Zhang - Journal of Fluorescence, 2024 - Springer
Photodynamic therapy (PDT) is an effective and US Food and Drug Administration (FDA)
approved treatment for cancer and other diseases. Photosensitizer is one of the three key …

A toolbox for enzymatic modification of nucleic acids with photosensitizers for photodynamic therapy

G Niogret, C Chériaux, F Bonhomme… - RSC Chemical …, 2024 - pubs.rsc.org
Photodynamic therapy (PDT) is an approved cancer treatment modality. Despite its high
efficiency, PDT is limited in terms of specificity and by the poor solubility of the rather …

Chemical probes for imaging cellular compartmentalization

MH Bülow, J Broichhagen - Trends in Biochemical Sciences, 2024 - cell.com
Chemical probes mark cellular compartments which have distinct interior environments and
membrane compositions. For examples of the former, rhodamine ester and cyanine …

Recent Progress in Thermally Activated Delayed Fluorescence Photosensitizers for Photodynamic Therapy

Z Li, J Lu, xuping Li - Chemistry–A European Journal, 2024 - Wiley Online Library
Photodynamic therapy (PDT) is a rapidly growing discipline that is expected to become an
encouraging noninvasive therapeutic strategy for cancer treatment. In the PDT process, an …