Lipoxygenases (LOXs) form a heterogeneous class of lipid peroxidizing enzymes, which
have been implicated not only in cell proliferation and differentiation but also in the …

Linoleic acid (LA) is a major constituent of low-density lipoproteins. An essential fatty acid,
LA is a polyunsaturated fatty acid, which is oxidised by endogenous enzymes and reactive …

Abstract Background Sodium butyrate (NaBu) is a short-chain fatty acid which serves as a
histon deacetylase inhibitor and has received considerable interest as a possible regulator …

Trichostatin A (TSA), a natural derivative of dienohydroxamic acid derived from a fungal
metabolite, exhibits various biological activities. It exerts antidiabetic activity and reverses …

Breast cancer represents one of the most common forms of cancer in women worldwide,
with an increase in the number of newly diagnosed patients in the last decade. The role of …

Simple Summary Histone deacetylases (HDACs) are epigenetic regulators that influence
chromatin structure and gene transcription, but also the function of non-histone targets like …

Resistance to cell death and reprogramming of metabolism are important in neoplastic cells.
Increased resistance to apoptosis and recurrence of tumors are the major roadblocks to …

Breast cancer, the most common cancer in the women, is the leading cause of death.
Necrotic signaling pathways will enable targeted therapeutic agents to eliminate apoptosis …

Abstract The 12/15-lipoxygenase (12/15-LOX) enzymes react with polyunsaturated fatty
acids producing active lipid metabolites that are involved in plethora of human diseases …

Estrogen promotes the development and survival of the majority of breast cancers (BCs).
Aromatase is the rate-limiting enzyme in estrogen biosynthesis, and it is immensely …