Cellular and molecular pathobiology of heart failure with preserved ejection fraction

S Mishra, DA Kass - Nature Reviews Cardiology, 2021 - nature.com
Heart failure with preserved ejection fraction (HFpEF) affects half of all patients with heart
failure worldwide, is increasing in prevalence, confers substantial morbidity and mortality …

Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American Society of Echocardiography and the …

SF Nagueh, OA Smiseth, CP Appleton… - European Journal of …, 2016 - academic.oup.com
Echocardiographic assessment of left ventricular (LV) diastolic function is an integral part of
the routine evaluation of patients presenting with symptoms of dyspnea or heart failure. The …

Atrial dysfunction in patients with heart failure with preserved ejection fraction and atrial fibrillation

YNV Reddy, M Obokata, FH Verbrugge, G Lin… - Journal of the American …, 2020 - jacc.org
Background Paroxysmal and permanent atrial fibrillation (AF) are common in heart failure
with preserved ejection fraction (HFpEF). Objectives This study sought to determine the …

Evidence supporting the existence of a distinct obese phenotype of heart failure with preserved ejection fraction

M Obokata, YNV Reddy, SV Pislaru, V Melenovsky… - Circulation, 2017 - Am Heart Assoc
Background: Heart failure (HF) with preserved ejection fraction (HFpEF) is a heterogeneous
syndrome. Phenotyping patients into pathophysiologically homogeneous groups may …

Heart failure with preserved ejection fraction: mechanisms and treatment strategies

K Omote, FH Verbrugge… - Annual review of medicine, 2022 - annualreviews.org
Approximately half of all patients with heart failure (HF) have a preserved ejection fraction,
and the prevalence is growing rapidly given the aging population in many countries and the …

Heart failure with preserved ejection fraction: from mechanisms to therapies

CSP Lam, AA Voors, RA de Boer… - European heart …, 2018 - academic.oup.com
This review aims to provide a translational perspective on recent developments in heart
failure with preserved ejection fraction (HFpEF), linking mechanistic insights to potential …

Diastolic dysfunction and heart failure with preserved ejection fraction: understanding mechanisms by using noninvasive methods

M Obokata, YNV Reddy, BA Borlaug - JACC: Cardiovascular Imaging, 2020 - jacc.org
Research in the last decade has substantially advanced our understanding of the
pathophysiology of heart failure with preserved ejection fraction (HFpEF). However …

Hemodynamic and functional impact of epicardial adipose tissue in heart failure with preserved ejection fraction

KE Koepp, M Obokata, YNV Reddy, TP Olson… - Heart Failure, 2020 - jacc.org
Objectives This study determined the impact of excess epicardial adipose tissue (EAT) in
patients with the obese phenotype of heart failure with preserved ejection fraction (HFpEF) …

Heart failure with preserved ejection fraction and atrial fibrillation: vicious twins

D Kotecha, CSP Lam, DJ Van Veldhuisen… - Journal of the American …, 2016 - jacc.org
Heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF) are age-
related conditions that are increasing in prevalence, commonly coexist, and share clinical …

The pathophysiology of heart failure with preserved ejection fraction

BA Borlaug - Nature Reviews Cardiology, 2014 - nature.com
Approximately half of all patients with heart failure have preserved ejection fraction (HFpEF)
and, as life expectancies continue to increase in western societies, the prevalence of HFpEF …