A review of bisindolylmethane as an important scaffold for drug discovery
Bisindolylmethane and its derivatives are pharmacologically active and applicable in the
field of pharmaceutical chemistry. Bisindolylmethanes have a variety of biological activities …
field of pharmaceutical chemistry. Bisindolylmethanes have a variety of biological activities …
Carbonic anhydrase inhibitory properties of novel benzylsulfamides using molecular modeling and experimental studies
In this study, a series of sulfamoyl carbamates and sulfamide derivatives were synthesized.
Six commercially available benzyl amines and BnOH were reacted with chlorosulfonyl …
Six commercially available benzyl amines and BnOH were reacted with chlorosulfonyl …
Significant pharmacological activities of benzoquinazolines scaffold
HA Abuelizz, R Al-Salahi - Pharmacological Reports, 2023 - Springer
Benzoquinazolines, the essential constituents of numerous well-known heterocyclic
systems, have occupied a prominent position and played a significant part in the synthesis of …
systems, have occupied a prominent position and played a significant part in the synthesis of …
Biological evaluation of p-toluene sulphonylhydrazone as carbonic anhydrase IX inhibitors: An approach to fight hypoxia-induced tumors
To find potential inhibitors of human carbonic anhydrase IX (CAIX), we have successfully
deigned, synthesized and characterized three p-toluene sulphonylhydrazone derivatives (1 …
deigned, synthesized and characterized three p-toluene sulphonylhydrazone derivatives (1 …
Synthesis, biological evaluation, and docking studies of novel thiourea derivatives of bisindolylmethane as carbonic anhydrase II inhibitor
This article describes discovery of 29 novel bisindolylmethanes consisting of thiourea
moiety, which had been synthesized through three steps. These novel bisindolylmethane …
moiety, which had been synthesized through three steps. These novel bisindolylmethane …
Inhibition of mammalian carbonic anhydrases I-XIV with grayanotoxin III: solution and in silico studies
Grayanotoxin III (GTX3) was investigated for inhibition of all catalytically active mammalian
carbonic anhydrase (CA, EC 4.2. 1.1) isoforms, ie CA I to CA XIV. It showed micromolar …
carbonic anhydrase (CA, EC 4.2. 1.1) isoforms, ie CA I to CA XIV. It showed micromolar …
The synthesis of new oxindoles as analogs of natural product 3,3-bis(indolyl)oxindole and in vitro evaluation of the enzyme activity of G6PD and 6PGD
Natural and synthetic derivatives that contain an indole core are being used in medical
treatments and technological processes. Therefore, the development of new synthetic …
treatments and technological processes. Therefore, the development of new synthetic …
[HTML][HTML] Molecular docking and inhibition profiles of some antidepressants on human carbonic anhydrase enzymes
A Atasever - Results in Chemistry, 2023 - Elsevier
Inhibition of human carbonic anhydrase (hCA) enzymes is a bright target since these
isoenzymes take part in various physiological events and inhibitors of these enzymes are …
isoenzymes take part in various physiological events and inhibitors of these enzymes are …
Synthesis of Tryptamine-Thiazolidin-4-one Derivatives and the Combined In Silico and In Vitro Evaluation of their Biological Activity and Cytotoxicity
Tryptamine, a monoamine alkaloid with an indole ring structure, is derived from the
decarboxylation of the amino acid tryptophan, which is present in fungi, plants, and animals …
decarboxylation of the amino acid tryptophan, which is present in fungi, plants, and animals …
Synthesis of novel bisindolylmethanes: New carbonic anhydrase II inhibitors, docking, and 3D pharmacophore studies
In this study, 45 bisindolylmethanes having sulfonamide moiety had been synthesized
through 3 steps. In vitro assay for inhibition of carbonic anhydrase showed that some of the …
through 3 steps. In vitro assay for inhibition of carbonic anhydrase showed that some of the …