Analysis of macromolecular/small-molecule binding pockets can provide important insights
into molecular recognition and receptor dynamics. Since its release in 2011, the POVME …

The precise mechanism by which propofol enhances GABAergic transmission remains
unclear, but much progress has been made regarding the underlying structural and dynamic …

Pentameric ligand-gated ion channels (pLGICs) of the Cys-loop receptor family are key
players in fast signal transduction throughout the nervous system. They have been shown to …

Alcohols and other anesthetic agents dramatically alter neurologic function in a wide range
of organisms, yet their molecular sites of action remain poorly characterized. Pentameric …

The α7 nicotinic acetylcholine receptor (α7nAChR) mediates signaling in the central nervous
system and cholinergic anti-inflammatory pathways. Ivermectin is a positive allosteric …

Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that play an
important role in signal transduction at the neuromuscular junction (NMJ). Movement of the …

The cellular membrane constitutes the first element that encounters a wide variety of
molecular species to which a cell might be exposed. Hosting a large number of structurally …

Structural rearrangements underlying functional transitions of pentameric ligand-gated ion
channels (pLGICs) are not fully understood. Using 19 F nuclear magnetic resonance and …

Most general anesthetics enhance GABA type A (GABA A) receptor activity at clinically
relevant concentrations. Sites of action of volatile anesthetics on the GABA A receptor …

Ligand-gated ion channels conduct currents in response to chemical stimuli, mediating
electrochemical signaling in neurons and other excitable cells. For many channels, the …