Type 1 diabetes affects millions of people globally and requires careful management to
avoid serious long-term complications, including heart and kidney disease, stroke, and loss …

The worldwide incidence of bone disorders and conditions has trended steeply upward and
is expected to double by 2020, especially in populations where aging is coupled with …

Here, we report the synthesis and characterization of size-controllable and stimuli-
responsive DNA nanohydrogels as effective targeted gene delivery vectors. DNA …

Gene therapy is a promising new technique for treating many serious incurable diseases,
such as cancer and genetic disorders. The main problem limiting the application of this …

There has been increasing interest in complex coacervates for deriving and transporting
biomaterials. Complex coacervates are a dense, polyelectrolyte‐rich liquid that results from …

Chitosan is a linear polysaccharide composed of randomly distributed β-(1-4)-linked d-
glucosamine and N-acetyl-d-glucosamine. It is one of the major cationic polymers and the …

Among non-viral vectors, chitosan and chitosan derivatives have been developed in vitro
and in vivo for DNA and siRNA delivery systems because of their cationic charge …

Gene therapy has emerged as a promising approach for the treatment or prevention of
acquired and genetic diseases. At the present time, major somatic gene transfer approaches …

Many drug targets are localized to particular subcellular compartments, yet current drug
design strategies are focused on bioavailability and tissue targeting and rarely address drug …

Functional siRNAs are employed as cross‐linkers to direct the self‐assembly of DNA‐
grafted polycaprolactone (DNA‐g‐PCL) brushes to form spherical and nanosized hydrogels …