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Respiratory depression limits the use of opioid analgesia. Although well described clinically,
the specific mechanisms of opioid action on respiratory control centres in the brain have …

The formulation of medicines for children remains a challenge. An ideal pediatric formulation
must allow accurate dose administration and be in a dosage form that can be handled by the …

Opioid use disorder continues to be a significant source of morbidity and mortality in the
USA and the world. Pharmacologic treatment with methadone and buprenorphine has been …

This paper is the 29th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning 30 years of research. It summarizes papers …

Pediatric palliative care (PPC) is provided to children experiencing life-limiting diseases
(LLD) or life-threatening diseases (LTD). Sixty to 90% of children with LLD/LTD undergoing …

STUDY OBJECTIVE: The impact of prescription opioid abuse on young children is
underrecognized and poorly documented. We hypothesize that poisoning of young children …

Background: Prescription medication abuse is an increasingly recognized problem in the
United States. As more opioids are being prescribed and abused by adults, there is an …

The purpose of this article was to characterize practices of buprenorphine/naloxone (B/N)
diversion in a region with a high prescribing prevalence. A cross-sectional, open-ended …

Compelling clinical evidence establishes that buprenorphine is similar to methadone in
efficacy for opiate detoxification and maintenance but safer than methadone in an overdose …