Stroke is a leading cause of the adult disability epidemic in the United States, with a major
contribution from poststroke cognitive impairment and dementia (PSCID), the rates of which …

Autophagy is a conserved degradation process crucial to maintaining the primary function of
cellular and organismal metabolism. Impaired autophagy could develop numerous …

Abstract The Rotterdam Study is an ongoing prospective cohort study that started in 1990 in
the city of Rotterdam, The Netherlands. The study aims to unravel etiology, preclinical …

INTRODUCTION White matter in the human brain serves a critical role in organizing
distributed neural networks. Diffusion magnetic resonance imaging (dMRI) has enabled the …

Abstract Amyloid-beta 42 (Aβ42) and phosphorylated tau (pTau) levels in cerebrospinal fluid
(CSF) reflect core features of the pathogenesis of Alzheimer's disease (AD) more directly …

International Journal of Epidemiology, 2023, e66–e79 https://doi. org/10.1093/ije/dyac114
Advance Access Publication Date: 28 May 2022 Cohort Profile comprehensive molecular …

Studies of the genetic regulation of cerebrospinal fluid (CSF) proteins may reveal pathways
for treatment of neurological diseases. 398 proteins in CSF were measured in 1,591 …

We have previously identified a network of higher-order brain regions particularly vulnerable
to the ageing process, schizophrenia and Alzheimer's disease. However, it remains …

The cerebral ventricles are recognized as windows into brain development and disease, yet
their genetic architectures, underlying neural mechanisms and utility in maintaining brain …

The cellular mechanisms underlying axonal morphogenesis are essential to the formation of
functional neuronal networks. We previously identified the autism-linked kinase NUAK1 as a …