Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects

C Li, P Jiang, S Wei, X Xu, J Wang - Molecular cancer, 2020 - Springer
Regulatory T cells (Tregs) characterized by the expression of the master transcription factor
forkhead box protein p3 (Foxp3) suppress anticancer immunity, thereby hindering protective …

Evaluation of regulatory T-cells in cancer immunotherapy: therapeutic relevance of immune checkpoint inhibition

R Singh, P Srivastava, PP Manna - Medical Oncology, 2024 - Springer
The evolution of the complex immune system is equipped to defend against perilous
intruders and concurrently negatively regulate the deleterious effect of immune-mediated …