Triazole-based drugs are a dynamic class of compounds exhibiting extensive therapeutic
potential. This comprehensive review explores the synthesis, application, FDA approvals …

Click chemistry is a flexible method featuring only the most feasible and efficient chemical
reactions. The synthesis of 1, 2, 3-triazole from azides and terminal acetylenes using copper …

Quinoline has been proposed as a privileged molecular framework in medicinal chemistry.
Although by itself it has very few applications, its derivatives have diverse biological …

Fungal infections cause severe and life-threatening complications especially in
immunocompromised individuals. Antifungals targeting cellular machinery and cell …

A series of new lanthanide (III) coordination polymers with the general formula [Ln (btrm) 2
(NO3) 3] n, where btrm= bis (1, 2, 4-triazol-1-yl) methane and Ln= Eu3+, Tb3+, Sm3+, Dy3+ …

Azole antifungals remain the “gold standard” therapy for invasive aspergillosis. The world-
wide emergence of isolates resistant to this drug class, however, developed into a steadily …

N-Heterocycles stand out in medicinal chemistry as significant pharmacophores because of
their wide biological potential and structural diversity. In this perspective, we have …

Invasive fungal infections pose a serious threat to public health and are associated with high
mortality and incidence rates. The development of novel antifungal agents is urgently …

Background Candida albicans is a fungal pathogen causing human infections. Here we
investigated differential gene expression patterns and functional enrichment in C. albicans …

Limited antifungal treatment options and drug resistance require innovative approaches to
effectively combat fungal infections. Combination therapy is a promising strategy that …