Formin proteins were recognized as effectors of Rho GTPases some 15 years ago. They
contribute to different cellular actin cytoskeleton structures by their ability to polymerize …

The restoration of myelin sheaths on demyelinated axons remains a major obstacle in the
treatment of multiple sclerosis (MS). Currently approved therapies work by modulating the …

Osteoporosis is a common aging-related disease diagnosed primarily using bone mineral
density (BMD). We assessed genetic determinants of BMD as estimated by heel quantitative …

Wnt signaling determines major developmental processes in the embryonic state and
regulates maintenance, self-renewal and differentiation of adult mammalian tissue stem …

Diagnosis and treatment of circadian rhythm sleep-wake disorders both require assessment
of circadian phase of the brain's circadian pacemaker. The gold-standard univariate method …

Osteocytes are master regulators of the skeleton. We mapped the transcriptome of
osteocytes from different skeletal sites, across age and sexes in mice to reveal genes and …

Polychlorinated biphenyls (PCBs) are developmental neurotoxicants implicated as
environmental risk factors for neurodevelopmental disorders (NDDs). Here, we report the …

Introduction Synapse loss is the structural correlate of the cognitive decline indicative of
dementia. In the brains of Alzheimer's disease sufferers, amyloid β (Aβ) peptides aggregate …

Bone morphogenetic proteins (BMPs) are secreted regulators of cell fate in several
developing tissues. In the embryonic spinal cord, they control the emergence of the neural …

Wnt signaling plays an essential role in developmental and regenerative myelination in the
central nervous system. The Wnt signaling pathway is composed of multiple regulatory …