Time-restricted eating for the prevention and management of metabolic diseases

ENC Manoogian, LS Chow, PR Taub… - Endocrine …, 2022 - academic.oup.com
Time-restricted feeding (TRF, animal-based studies) and time-restricted eating (TRE,
humans) are an emerging behavioral intervention approach based on the understanding of …

Transcriptional architecture of the mammalian circadian clock

JS Takahashi - Nature Reviews Genetics, 2017 - nature.com
Circadian clocks are endogenous oscillators that control 24-hour physiological and
behavioural processes in organisms. These cell-autonomous clocks are composed of a …

Circadian clock genes and the transcriptional architecture of the clock mechanism

KH Cox, JS Takahashi - Journal of molecular endocrinology, 2019 - jme.bioscientifica.com
The mammalian circadian clock has evolved as an adaptation to the 24-h light/darkness
cycle on earth. Maintaining cellular activities in synchrony with the activities of the organism …

Clocking in to immunity

C Scheiermann, J Gibbs, L Ince… - Nature Reviews …, 2018 - nature.com
Circadian rhythms are a ubiquitous feature of virtually all living organisms, regulating a wide
diversity of physiological systems. It has long been established that the circadian clockwork …

The functional and clinical significance of the 24-hour rhythm of circulating glucocorticoids

H Oster, E Challet, V Ott, E Arvat, ER de Kloet… - Endocrine …, 2017 - academic.oup.com
Adrenal glucocorticoids are major modulators of multiple functions, including energy
metabolism, stress responses, immunity, and cognition. The endogenous secretion of …

[HTML][HTML] Timing to perfection: the biology of central and peripheral circadian clocks

U Albrecht - Neuron, 2012 - cell.com
The mammalian circadian system, which is comprised of multiple cellular clocks located in
the organs and tissues, orchestrates their regulation in a hierarchical manner throughout the …

The mammalian circadian system: a hierarchical multi-oscillator structure for generating circadian rhythm

S Honma - The Journal of Physiological Sciences, 2018 - Springer
The circadian nature of physiology and behavior is regulated by a circadian clock that
generates intrinsic rhythms with a periodicity of approximately 24 h. The mammalian …

Suprachiasmatic nucleus: cell autonomy and network properties

DK Welsh, JS Takahashi, SA Kay - Annual review of physiology, 2010 - annualreviews.org
The suprachiasmatic nucleus (SCN) is the primary circadian pacemaker in mammals.
Individual SCN neurons in dispersed culture can generate independent circadian …

[HTML][HTML] The genomic landscape and pharmacogenomic interactions of clock genes in cancer chronotherapy

Y Ye, Y Xiang, FM Ozguc, Y Kim, CJ Liu, PK Park, Q Hu… - Cell systems, 2018 - cell.com
Cancer chronotherapy, treatment at specific times during circadian rhythms, endeavors to
optimize anti-tumor effects and to lower toxicity. However, comprehensive characterization of …

Molecular components of the mammalian circadian clock

CH Ko, JS Takahashi - Human molecular genetics, 2006 - academic.oup.com
Circadian rhythms are∼ 24-h oscillations in behavior and physiology, which are internally
generated and function to anticipate the environmental changes associated with the solar …