Molecular biomarkers for embryonic and adult neural stem cell and neurogenesis

J Zhang, J Jiao - BioMed research international, 2015 - Wiley Online Library
The procedure of neurogenesis has made numerous achievements in the past decades,
during which various molecular biomarkers have been emerging and have been broadly …

The astrocyte odyssey

DD Wang, A Bordey - Progress in neurobiology, 2008 - Elsevier
Neurons have long held the spotlight as the central players of the nervous system, but we
must remember that we have equal numbers of astrocytes and neurons in the brain. Are …

Gingival mesenchymal stem/progenitor cells: a unique tissue engineering gem

KM Fawzy El-Sayed, CE Dörfer - Stem cells international, 2016 - Wiley Online Library
The human gingiva, characterized by its outstanding scarless wound healing properties, is a
unique tissue and a pivotal component of the periodontal apparatus, investing and …

Kisspeptin signaling in astrocytes modulates the reproductive axis

E Torres, G Pellegrino, M Granados-Rodríguez… - The Journal of Clinical …, 2024 - jci.org
Reproduction is safeguarded by multiple, often cooperative, regulatory networks. Kisspeptin
signaling, via KISS1R, plays a fundamental role in reproductive control, primarily by …

Mitigating off-target effects in CRISPR/Cas9-mediated in vivo gene editing

HA Han, JKS Pang, BS Soh - Journal of Molecular Medicine, 2020 - Springer
The rapid advancement of genome editing technologies has opened up new possibilities in
the field of medicine. Nuclease-based techniques such as the CRISPR/Cas9 system are …

[HTML][HTML] The current state of biomarkers of mild traumatic brain injury

HJ Kim, JW Tsao, AG Stanfill - JCI insight, 2018 - ncbi.nlm.nih.gov
Mild traumatic brain injury (mTBI) is a common occurrence, with over 3 million cases
reported every year in the United States. While research into the underlying pathophysiology …

Brain and testis: more alike than previously thought?

B Matos, SJ Publicover, LFC Castro… - Advances in Surgical …, 2023 - taylorfrancis.com
The human body is an orchestrated set of different organs that work together, contributing to
the maintenance of overall health and homeostasis. The human brain is the control center of …

Progenitor cells of the testosterone-producing Leydig cells revealed

MS Davidoff, R Middendorff, G Enikolopov… - The Journal of cell …, 2004 - rupress.org
The cells responsible for production of the male sex hormone testosterone, the Leydig cells
of the testis, are post-mitotic cells with neuroendocrine characteristics. Their origin during …

Characterization of Nestin-positive stem Leydig cells as a potential source for the treatment of testicular Leydig cell dysfunction

MH Jiang, B Cai, Y Tuo, J Wang, ZJ Zang, X Tu, Y Gao… - Cell research, 2014 - nature.com
The ability to identify and isolate lineage-specific stem cells from adult tissues could facilitate
cell replacement therapy. Leydig cells (LCs) are the primary source of androgen in the …

Origin, development and regulation of human Leydig cells

K Svechnikov, L Landreh, J Weisser, G Izzo… - Hormone research in …, 2010 - karger.com
Sex steroids are crucial regulators of sexual differentiation and the proper development of
secondary sex characteristics and patterns of sexual behavior. Since Leydig cells are the …