After a myocardial infarction, the boundary between the injured, hypoxic tissue and the
adjacent viable, normoxic tissue, known as the border zone, is characterized by an oxygen …

As regulatory bodies encourage alternatives to animal testing, there is renewed interest in
engineering disease models, particularly for cardiac tissues. The aligned organization of …

Abstract Live cell calcium (Ca2+) imaging is one of the important tools to record cellular
activity during in vitro and in vivo preclinical studies. Specially, high-resolution microscopy …

Geometry and mechanical characteristics of the environment surrounding the Engineered
Heart Tissues (EHT) affect their structure and function. Here, we employed a 3D tissue …

Controlled electrical stimulation is essential for evaluating the physiology of cardiac tissues
engineered in heart-on-a-chip devices. However, existing stimulation techniques, such as …

In vitro models of patient-derived muscle allow for more efficient development of genetic
medicines for the muscular dystrophies, which often present mutation-specific pathologies …

There is a growing interest in creating 2D cardiac tissue models that display native
extracellular matrix (ECM) cues of the heart tissue. Cellular alignment alone is known to be a …

The uterus is susceptible to benign tumors known as fibroids, which have been associated
with many pregnancy complications, including preterm labor. However, the impact of fibrotic …

Heart failure remains the world's leading cause of death worldwide, with limited treatment
options aside from palliation and a desperate need for effective preclinical models. The …

Many acquired or inherited forms of heart disease as well as drugs are known to increase
the susceptibility of patients to arrhythmias. To predict arrhythmogenic events and discover …