Duchenne muscular dystrophy (DMD) is a progressive muscle-wasting disorder. It is caused
by loss-of-function mutations in the dystrophin gene. Currently, there is no cure. A highly …

Cellular functions depend on numerous protein-coding and noncoding RNAs and the RNA-
binding proteins associated with them, which form ribonucleoprotein complexes (RNPs) …

Recently, a new regulatory circuitry has been identified in which RNAs can crosstalk with
each other by competing for shared microRNAs. Such competing endogenous RNAs …

Skeletal muscle atrophy is defined as a decrease in muscle mass and it occurs when protein
degradation exceeds protein synthesis. Potential triggers of muscle wasting are long-term …

Antisense‐mediated exon skipping aiming for reading frame restoration is currently a
promising therapeutic application for Duchenne muscular dystrophy (DMD). This approach …

The study of the muscle cell in the muscular dystrophies (MDs) has shown that mutant
proteins result in perturbations of many cellular components. MDs have been associated …

The use of splice‐switching antisense therapy is highly promising, with a wealth of pre‐
clinical data and numerous clinical trials ongoing. Nevertheless, its potential to treat a variety …

Dystrophin absence in Duchenne muscular dystrophy (DMD) causes severe muscle
degeneration. We describe that, as consequence of fibre damage, specific muscle‐miRNAs …

RNA mis-splicing diseases account for up to 15% of all inherited diseases, ranging from
neurological to myogenic and metabolic disorders. With greatly increased genomic …

In Duchenne muscular dystrophy (DMD) the absence of dystrophin at the sarcolemma
delocalizes and downregulates nitric oxide synthase (nNOS); this alters S-nitrosylation of …