Recent advances on biologically active coumarin-based hybrid compounds

M Yildirim, S Poyraz, M Ersatir - Medicinal Chemistry Research, 2023 - Springer
Coumarin hybrids have been designed and synthesized as an important new strategy in the
field of medicinal chemistry. Coumarin core has been shown to form various compounds to …

Novel beta-lactam substituted benzenesulfonamides: in vitro enzyme inhibition, cytotoxic activity and in silico interactions

Ö Güleç, C Türkeş, M Arslan, Y Demir… - Journal of …, 2023 - Taylor & Francis
In this study, a library of twelve beta-lactam-substituted benzenesulfonamides (5a–l) was
synthesized using the tail-approach method. The compounds were characterized using IR …

Sulfonamide a valid scaffold for antioxidant drug development

MC Egbujor, J Garrido, F Borges… - Mini-Reviews in Organic …, 2023 - ingentaconnect.com
Like the well-known sulfa drugs, Sulfonamides are ascribed to a myriad of biological
activities, including antioxidant activity. In fact, several tertiary sulfonamides, particularly N …

A mathematical model analysis of meningitis with treatment and vaccination in fractional derivatives

OJ Peter, A Yusuf, MM Ojo, S Kumar, N Kumari… - International Journal of …, 2022 - Springer
In this paper, we develop a new mathematical model based on the Atangana Baleanu
Caputo (ABC) derivative to investigate meningitis dynamics. We explain why fractional …

Quinazolinone-based benzenesulfonamides with low toxicity and high affinity as monoamine oxidase-A inhibitors: Synthesis, biological evaluation and induced-fit …

C Yamali, HI Gul, MT Sakarya, BN Saglik, A Ece… - Bioorganic …, 2022 - Elsevier
The research in selective monoamine oxidases (MAO-A and MAO-B) inhibitors has been
increased due to their therapeutic value for neurodegenerative diseases. In this study, 4-((2 …

Anticholinesterase and antioxidant activities of novel heterocyclic Schiff base derivatives containing an aryl sulfonate moiety

A Kamalı, R Çakmak, M Boğa - Journal of the Chinese …, 2022 - Wiley Online Library
In this research, nine novel heterocyclic Schiff base derivatives (10–18) bearing an aryl
sulfonate moiety were designed, synthesized for the first time, and characterized. Then, their …

Novel benzene sulfonamides with acetylcholinesterase and carbonic anhydrase inhibitory actions

R El Ati, N Öztaşkın, A Çağan, A Akıncıoğlu… - Archiv der …, 2024 - Wiley Online Library
A series of benzene sulfonamides 15–26 were synthesized and determined for their in vitro
and in silico inhibitory profiles toward acetylcholinesterase (AChE) and carbonic anhydrases …

Indole‐3‐carbinol (I3C): Inhibition effect on monoamine oxidase A (MAO‐A), monoamine oxidase B (MAO‐B) and cholinesterase enzymes, antioxidant capacity and …

EE Binici, H Akıncıoğlu, N Kılınç - ChemistrySelect, 2023 - Wiley Online Library
Monoamine oxidase A and B (MAO‐A and MAO‐B) isoenzymes play key roles in
neurodegenerative diseases like Parkinson's disease (PD) and Alzheimer's disease (AD) …

In silico study on antidiabetic and antioxidant activity of bioactive compounds in Ficus carica L

APS Raman, S Pongpaiboon, R Bhatia… - Journal of …, 2023 - Taylor & Francis
Hyperglycemia is one of the diagnostic issues in diabetes mellitus and is considered as a
complex metabolic condition. It has been one of the most prevalent illnesses of the twenty …

[HTML][HTML] Biorefinery approach with green solvents for the valorization of Citrus reticulata leaves to obtain antioxidant and anticholinergic extracts

G Domínguez-Rodríguez, VM Amador-Luna… - Food Chemistry, 2024 - Elsevier
Citrus reticulata L leaves are one of the main post-harvest byproduct, containing bioactive
compounds, that are usually undervalued. This work describes the development of a …