For almost a century, vitamin A has been known as a nutrient critical for normal
development, differentiation, and homeostasis; accordingly, there has been much interest in …

Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

Peroxisome proliferator-activated receptor 72 (PPARy2) is an adipocyte-specific nuclear
hormone receptor that has recently been identified as a key regulator of two fat cell …

NUCLEAR receptor coregulators are coactivators or corepressors that are required by
nuclear receptors for efficient transcriptional regulation. In this context, we define …

We have identified a new retinoid response pathway through which 9-cis retinoic acid
(9cRA) activates transcription in the presence of LXR alpha, a member of the nuclear …

The nuclear receptor (NR) superfamily of transcription factors regulates gene expression in
response to endocrine signaling, and recruitment of coregulators affords these receptors …

This review addresses recent developments regarding the peroxisome proliferator activated
receptors (PPARs). We will briefly review the older literature regarding the phenomenon of …

The binding of endogenous retinoids and stereoisomers of retinoic acid (RA) to the retinoid
nuclear receptors, RA receptor (RARs) and retinoid X receptors (RXRs), was characterized …

IN THE LATE 1980s and early 1990s, the elucidation of the molecular basis of acute
promyelocytic leukemia (APL) emerged as a paradigm for the connection between the …

The pleiotropic effects of retinoids are mediated by nuclear retinoid receptors (RARs and
RXRs) which are ligand-activated transcription factors. In response to retinoid binding …