Chemical synthesis of human proteoforms and application in biomedicine
H Ai, M Pan, L Liu - ACS Central Science, 2024 - ACS Publications
Limited understanding of human proteoforms with complex posttranslational modifications
and the underlying mechanisms poses a major obstacle to research on human health and …
and the underlying mechanisms poses a major obstacle to research on human health and …
Optimized and Robust Workflow for Quantifying the Canonical Histone Ubiquitination Marks H2AK119ub and H2BK120ub by LC–MS/MS
M Lopes, PJ Lund, BA Garcia - Journal of Proteome Research, 2024 - ACS Publications
The eukaryotic genome is packaged around histone proteins, which are subject to a myriad
of post-translational modifications. By controlling DNA accessibility and the recruitment of …
of post-translational modifications. By controlling DNA accessibility and the recruitment of …
[HTML][HTML] Interpreting Combinatorial Epigenetic Modifications for Biological Meaning
SM Lauberth, TG Kutateladze… - Journal of molecular …, 2024 - pmc.ncbi.nlm.nih.gov
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A Site‐Specific Click Chemistry Approach to Di‐Ubiquitylate H1 Variants Reveals Position‐Dependent Stimulation of the DNA Repair Protein RNF168
P Franz, CM Delvaux de Fenffe… - Angewandte Chemie …, 2024 - Wiley Online Library
Ubiquitylation of histone H2A at lysines 13 and 15 by the E3 ligase RNF168 plays a key role
in orchestrating DNA double‐strand break (DSB) repair, which is often deregulated in …
in orchestrating DNA double‐strand break (DSB) repair, which is often deregulated in …
Ein ortsspezifischer Click‐Chemie‐Ansatz zur Diubiquitylierung von H1‐Varianten zeigt eine positionsabhängige Stimulation des DNA‐Reparaturproteins RNF168
P Franz, CM Delvaux de Fenffe, B Fierz - Angewandte Chemie, 2024 - Wiley Online Library
Abstract Die Ubiquitylierung von Histon H2A an den Lysinen 13 und 15 (H2AK13/15) durch
die E3 Ligase RNF168 spielt eine entscheidende Rolle bei der Organisation der Reparatur …
die E3 Ligase RNF168 spielt eine entscheidende Rolle bei der Organisation der Reparatur …
Chemically di-ubiquitylated H1 variants reveal position-dependent stimulation of the DNA repair protein RNF168
Ubiquitylation of histone H2A at lysines 13 and 15 by the E3 ligase RNF168 plays a key role
in orchestrating DNA double-strand break (DSB) repair, which is often deregulated in …
in orchestrating DNA double-strand break (DSB) repair, which is often deregulated in …