[HTML][HTML] Quantitative susceptibility mapping of brain iron in healthy aging and cognition

DJ Madden, JL Merenstein - NeuroImage, 2023 - Elsevier
Quantitative susceptibility mapping (QSM) is a magnetic resonance imaging (MRI) technique
that can assess the magnetic properties of cerebral iron in vivo. Although brain iron is …

Quantitative susceptibility mapping as an imaging biomarker for Alzheimer's disease: The expectations and limitations

Y Uchida, H Kan, K Sakurai, K Oishi… - Frontiers in …, 2022 - frontiersin.org
Alzheimer's disease (AD) is the most common type of dementia and a distressing diagnosis
for individuals and caregivers. Researchers and clinical trials have mainly focused on β …

Assessment of 18F-PI-2620 as a biomarker in progressive supranuclear palsy

M Brendel, H Barthel, T van Eimeren, K Marek… - JAMA …, 2020 - jamanetwork.com
Importance Progressive supranuclear palsy (PSP) is a 4-repeat tauopathy. Region-specific
tau aggregates establish the neuropathologic diagnosis of definite PSP post mortem. Future …

Brain iron at quantitative MRI is associated with disability in multiple sclerosis

R Zivadinov, E Tavazzi, N Bergsland, J Hagemeier… - Radiology, 2018 - pubs.rsna.org
Purpose To study deep gray matter susceptibility in multiple sclerosis (MS) by using
quantitative susceptibility mapping (QSM) and to assess the relationship between …

[HTML][HTML] Investigation of the association between cerebral iron content and myelin content in normative aging using quantitative magnetic resonance neuroimaging

N Khattar, C Triebswetter, M Kiely, L Ferrucci… - Neuroimage, 2021 - Elsevier
Myelin loss and iron accumulation are cardinal features of aging and various
neurodegenerative diseases. Oligodendrocytes incorporate iron as a metabolic substrate for …

Unraveling the contributions to the neuromelanin-MRI contrast

N Priovoulos, SCJ van Boxel, HIL Jacobs… - Brain Structure and …, 2020 - Springer
Abstract The Locus Coeruleus (LC) and the Substantia Nigra (SN) are small brainstem
nuclei that change with aging and may be involved in the development of various …

[HTML][HTML] SEPIA—Susceptibility mapping pipeline tool for phase images

KS Chan, JP Marques - Neuroimage, 2021 - Elsevier
Quantitative susceptibility mapping (QSM) is a physics-driven computational technique that
has a high sensitivity in quantifying iron deposition based on MRI phase images …

MP2RAGEME: T1, T2*, and QSM mapping in one sequence at 7 tesla

MWA Caan, PL Bazin, JP Marques… - Human brain …, 2019 - Wiley Online Library
Quantitative magnetic resonance imaging generates images of meaningful physical or
chemical variables measured in physical units that allow quantitative comparisons between …

Binding characteristics of [18F]PI-2620 distinguish the clinically predicted tau isoform in different tauopathies by PET

M Song, L Beyer, L Kaiser, H Barthel… - Journal of cerebral …, 2021 - journals.sagepub.com
The novel tau-PET tracer [18F] PI-2620 detects the 3/4-repeat-(R)-tauopathy Alzheimer's
disease (AD) and the 4R-tauopathies corticobasal syndrome (CBS) and progressive …

R2* and quantitative susceptibility mapping in deep gray matter of 498 healthy controls from 5 to 90 years

S Treit, N Naji, P Seres, J Rickard, E Stolz… - Human Brain …, 2021 - Wiley Online Library
Putative MRI markers of iron in deep gray matter have demonstrated age related changes
during discrete periods of healthy childhood or adulthood, but few studies have included …