The epigenetics of aging and neurodegeneration
Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …
expression that do not involve changes in the genotype. Epigenetics is of increasing …
The dynamics of DNA methylation in schizophrenia and related psychiatric disorders
DR Grayson, A Guidotti - Neuropsychopharmacology, 2013 - nature.com
Major psychiatric disorders such as schizophrenia (SZ) and bipolar disorder (BP) with
psychosis (BP+) express a complex symptomatology characterized by positive symptoms …
psychosis (BP+) express a complex symptomatology characterized by positive symptoms …
Genome-wide DNA methylation comparison between live human brain and peripheral tissues within individuals
Differential DNA methylation in the brain is associated with many psychiatric diseases, but
access to brain tissues is essentially limited to postmortem samples. The use of surrogate …
access to brain tissues is essentially limited to postmortem samples. The use of surrogate …
Correspondence of DNA methylation between blood and brain tissue and its application to schizophrenia research
Given the difficulty of procuring human brain tissue, a key question in molecular psychiatry
concerns the extent to which epigenetic signatures measured in more accessible tissues …
concerns the extent to which epigenetic signatures measured in more accessible tissues …
Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder
Studies of the major psychoses, schizophrenia (SZ) and bipolar disorder (BD), have
traditionally focused on genetic and environmental risk factors, although more recent work …
traditionally focused on genetic and environmental risk factors, although more recent work …
Dynamic changes in DNA methylation of stress-associated genes (OXTR, BDNF) after acute psychosocial stress
Environmentally induced epigenetic alterations are related to mental health. We investigated
quantitative DNA methylation status before and after an acute psychosocial stressor in two …
quantitative DNA methylation status before and after an acute psychosocial stressor in two …
Epigenetic mechanisms in Alzheimer's disease
D Mastroeni, A Grover, E Delvaux, C Whiteside… - Neurobiology of …, 2011 - Elsevier
Epigenetic modifications help orchestrate sweeping developmental, aging, and disease-
causing changes in phenotype by altering transcriptional activity in multiple genes spanning …
causing changes in phenotype by altering transcriptional activity in multiple genes spanning …
DNA methylation and schizophrenia: current literature and future perspective
Schizophrenia is a neuropsychiatric disorder characterized by dissociation of thoughts, idea,
identity, and emotions. It has no central pathophysiological mechanism and precise …
identity, and emotions. It has no central pathophysiological mechanism and precise …
Epigenetic aberrations in leukocytes of patients with schizophrenia: association of global DNA methylation with antipsychotic drug treatment and disease onset
Even though schizophrenia has a strong hereditary component, departures from simple
genetic transmission are prominent. DNA methylation has emerged as an epigenetic …
genetic transmission are prominent. DNA methylation has emerged as an epigenetic …
Epigenetic research in neuropsychiatric disorders: the “tissue issue”
KM Bakulski, A Halladay, VW Hu, J Mill… - Current behavioral …, 2016 - Springer
Abstract Purpose of Review Evidence has linked neuropsychiatric disorders with epigenetic
marks as either a biomarker of disease, biomarker of exposure, or mechanism of disease …
marks as either a biomarker of disease, biomarker of exposure, or mechanism of disease …