Oxygen-derived free radicals and related oxidants are ubiquitous and short-lived
intermediates formed in aerobic organisms throughout life. These reactive species …

Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

Nitric oxide (NO) and hydrogen sulfide (H 2 S) are gasotransmitters, which are involved in
almost all plant physiological and stress-related processes. With its antioxidant regulatory …

In this review we provide an analysis of the biochemistry of peroxynitrite and tyrosine
nitration. Peroxynitrite is the product of the diffusion-controlled reaction between superoxide …

Over the last decade, a dual character of cell response to oxidative stress, eustress versus
distress, has become increasingly recognized. A growing body of evidence indicates that …

The free radical nitric oxide (NO•) exerts biological effects through the direct and reversible
interaction with specific targets (eg soluble guanylate cyclase) or through the generation of …

Potent immunosuppressive mechanisms within the tumor microenvironment contribute to the
resistance of aggressive human cancers to immune checkpoint blockade (ICB) therapy. One …

The global concept of oxidative stress is defined as “an imbalance between oxidants and
antioxidants in favor of the oxidants, leading to a disruption of redox signaling and control …

This review examines the impact of reactive species RS (of oxygen ROS, nitrogen RNS and
halogens RHS) on various amino acids, analyzed from a reactive point of view of how during …

Oxidative and nitrosative stress are widely recognized as critical factors in the pathogenesis
and progression of Alzheimer disease (AD) and its earlier stage, amnestic mild cognitive …