Targeting the latent reservoir for HIV-1
S Sengupta, RF Siliciano - Immunity, 2018 - cell.com
Antiretroviral therapy can effectively block HIV-1 replication and prevent or reverse
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …
HIV latency
RF Siliciano, WC Greene - Cold Spring …, 2011 - perspectivesinmedicine.cshlp.org
HIV-1 can establish a state of latent infection at the level of individual T cells. Latently
infected cells are rare in vivo and appear to arise when activated CD4+ T cells, the major …
infected cells are rare in vivo and appear to arise when activated CD4+ T cells, the major …
Clonally expanded HIV-1 proviruses with 5′-leader defects can give rise to nonsuppressible residual viremia
Background Antiretroviral therapy (ART) halts HIV-1 replication, decreasing viremia to below
the detection limit of clinical assays. However, some individuals experience persistent …
the detection limit of clinical assays. However, some individuals experience persistent …
Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies
HIV-1 reservoirs preclude virus eradication in patients receiving highly active antiretroviral
therapy (HAART). The best characterized reservoir is a small, difficult-to-quantify pool of …
therapy (HAART). The best characterized reservoir is a small, difficult-to-quantify pool of …
Proviruses with identical sequences comprise a large fraction of the replication-competent HIV reservoir
JK Bui, MD Sobolewski, BF Keele, J Spindler… - PLoS …, 2017 - journals.plos.org
The major obstacle to curing HIV infection is the persistence of cells with intact proviruses
that can produce replication-competent virus. This HIV reservoir is believed to exist primarily …
that can produce replication-competent virus. This HIV reservoir is believed to exist primarily …
Immune activation and HIV persistence: implications for curative approaches to HIV infection
NR Klatt, N Chomont, DC Douek… - Immunological …, 2013 - Wiley Online Library
Despite complete or near‐complete suppression of human immunodeficiency virus (HIV)
replication with combination antiretroviral therapy, both HIV and chronic …
replication with combination antiretroviral therapy, both HIV and chronic …
Latency reversal and viral clearance to cure HIV-1
DM Margolis, JV Garcia, DJ Hazuda, BF Haynes - Science, 2016 - science.org
BACKGROUND A central challenge to emerging efforts to cure HIV infection is the
persistence of quiescent but replication-competent proviral genomes in resting CD4+ T …
persistence of quiescent but replication-competent proviral genomes in resting CD4+ T …
The HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time
L Josefsson, S Von Stockenstrom… - Proceedings of the …, 2013 - National Acad Sciences
The source and dynamics of persistent HIV-1 during long-term combinational antiretroviral
therapy (cART) are critical to understanding the barriers to curing HIV-1 infection. To …
therapy (cART) are critical to understanding the barriers to curing HIV-1 infection. To …
Immunologic basis of cardiovascular disease in HIV-infected adults
Cardiovascular complications are more common in human immunodeficiency virus–infected
individuals than in age-matched uninfected individuals. Antiretroviral therapy reduces the …
individuals than in age-matched uninfected individuals. Antiretroviral therapy reduces the …
HIV-1 DNA decay dynamics in blood during more than a decade of suppressive antiretroviral therapy
GJ Besson, CM Lalama, RJ Bosch… - Clinical Infectious …, 2014 - academic.oup.com
Background. Human immunodeficiency virus type 1 (HIV-1) DNA dynamics during long-term
antiretroviral therapy (ART) are not defined. Methods. Blood mononuclear cells obtained …
antiretroviral therapy (ART) are not defined. Methods. Blood mononuclear cells obtained …