The removal of unwanted or damaged mitochondria by autophagy, a process called
mitophagy, is essential for key events in development, cellular homeostasis, tumor …

INTRODUCTION Mutations in two genes, PKD1 and PKD2, are responsible for about 85 and
10% of all cases of autosomal dominant polycystic kidney disease (ADPKD), one of the most …

Tandem affinity purification (TAP) is a methodology for the isolation of protein complexes
from endogenous sources. It involves incorporation of a dual-affinity tag into the protein of …

Cellular organelles provide opportunities to relate biological mechanisms to disease. Here
we use affinity proteomics, genetics and cell biology to interrogate cilia: poorly understood …

Leucine-rich repeat kinase 2 (LRRK2) is a large, multidomain protein containing two
catalytic domains: a Ras of complex proteins (Roc) G-domain and a kinase domain …

The cilium is an essential organelle at the surface of mammalian cells whose dysfunction
causes a wide range of genetic diseases collectively called ciliopathies. The current rate at …

Recycling of endocytic receptors to the cell surface involves passage through a series of
membrane-bound compartments by mechanisms that are poorly understood. In particular, it …

Accumulation of protein-and lipid-containing deposits external to the retinal pigment
epithelium (RPE) is common in the aging eye, and has long been viewed as the hallmark of …

Regional lymph node metastasis negatively affects prognosis in colon cancer patients. The
molecular processes leading to regional lymph node metastasis are only partially …

Mutations in human leucine-rich repeat kinase 2 (Lrrk2), a protein of yet unknown function,
are linked to Parkinson's disease caused by degeneration of midbrain dopaminergic …