Yessotoxin (YTX) is a polyether compound produced by dinoflagellates and accumulated in
filter feeding shellfish. No records about human intoxications induced by this compound …

Background: Key challenges of biopsy-based determination of prostate cancer
aggressiveness include tumour heterogeneity, biopsy-sampling error, and variations in …

Cell division relies on coordinated regulation of the cell cycle. A process including a well-
defined series of strictly regulated molecular mechanisms involving cyclin-dependent …

Correct orientation of the mitotic spindle in stem cells underlies organogenesis. Spindle
abnormalities correlate with cancer progression in germ line-derived tumors. We discover a …

Brain tumor glioblastoma has no clear molecular signature and there is no effective therapy.
In rodents, the intracellular distribution of the cyclic AMP (cAMP)-dependent protein kinase …

Mitogenic signals that regulate cell division often proceed through multienzyme assemblies
within defined intracellular compartments. The anchoring protein Gravin restricts the action …

2012-07-09 Assigned to DANA-FARBER CANCER INSTITUTE, INC. reassignment DANA-
FARBER CANCER INSTITUTE, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE …

A functional endothelium must maintain an equilibrium among processes such as
endothelial cell (EC) migration, barrier function and angiogenesis. The endothelium is …

Fundamental cellular processes such as cell division, migration, differentiation, and growth
require environmental signals to be converted into chemical responses that generate …

Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation and
airway inflammation. Since the current medications are not always effective and fail to …