1H-Pyrazolo[3,4-b]pyridines: Synthesis and Biomedical Applications

A Donaire-Arias, AM Montagut, R Puig de la Bellacasa… - Molecules, 2022 - mdpi.com
Pyrazolo [3, 4-b] pyridines are a group of heterocyclic compounds presenting two possible
tautomeric forms: the 1 H-and 2 H-isomers. More than 300,000 1 H-pyrazolo [3, 4-b] …

Exploring quinoxaline derivatives: An overview of a new approach to combat antimicrobial resistance

H Khatoon, SMM Faudzi - European journal of medicinal chemistry, 2024 - Elsevier
Antimicrobial resistance (AMR) has emerged as a long-standing global issue ever since the
introduction of penicillin, the first antibiotic. Scientists are constantly working to develop …

Design, synthesis, in-silico and biological evaluation of novel 2-Amino-1, 3, 4-thiadiazole based hydrides as B-cell lymphoma-2 inhibitors with potential anticancer …

SA Ibrahim, MM Salem, HA Abd Elsalam… - Journal of Molecular …, 2022 - Elsevier
Abstract In the current study, 5-(pyridin-2-yl)-1, 3, 4-thiadiazol-2-amine (1) was synthesized
via one step reaction of picolinic acid with thiosemicarbazide in the presence of POCl 3 …

New imidazole-2-ones and their 2-thione analogues as anticancer agents and CAIX inhibitors: Synthesis, in silico ADME and molecular modeling studies

SA Ibrahim, SR Al-Mhyawi, FM Atlam - Bioorganic Chemistry, 2023 - Elsevier
The present study involves the synthesis of a series of new imidazole-2-ones derivatives
and their 2-thione analogs using conventional heating and the environmentally friendly …

Structure based design and synthesis of 3-(7-nitro-3-oxo-3, 4-dihydroquinoxalin-2-yl) propanehydrazide derivatives as novel bacterial DNA-gyrase inhibitors: In-vitro …

MA Saleh, AA Elmaaty, HS El Saeed, MM Saleh… - Bioorganic …, 2022 - Elsevier
Antimicrobial resistance (AMR) is one of the critical challenges that have been encountered
over the past years. On the other hand, bacterial DNA gyrase is regarded as one of the most …

A green approach for the catalyst‐free synthesis of imidazole‐bearing pyrazole moiety using PEG‐400 as an efficient recyclable medium as potential anti‐tubercular …

NM Panchani, KM Kapadiya… - Journal of Heterocyclic …, 2022 - Wiley Online Library
Abstract Polyethylene glycol‐400 (PEG‐400) is a recyclable and rapid reaction medium for
synthesizing a new series of 4‐(3‐[substitutedphenyl]‐4, 5‐dihydro‐1‐phenyl‐1 H‐pyrazol …

Antibacterial and Antifungal Pyrazoles Based on Different Construction Strategies

MU Rehman, F He, X Shu, J Guo, Z Liu, S Cao… - European Journal of …, 2024 - Elsevier
The growing prevalence of microbial infections, and antimicrobial resistance (AMR)
stemming from the overuse and misuse of antibiotics, call for novel therapeutic agents …

New Pyrazolothiazole as Potential Wnt/β‐Catenin Inhibitors: Green Synthesis, Characterization, Antimicrobial, Antioxidant, Antineoplastic Evaluation, and Molecular …

AA Noser, MH Baren, SA Ibrahim, M Rekaby… - …, 2023 - Wiley Online Library
In our attempt to develop potential new drug candidates with promising antimicrobial,
antioxidant, and anticancer activities, a series of novel pyrazolothiazole derivatives (PTDs) …

Design, synthesis, theoretical study, antioxidant, and anticholinesterase activities of new pyrazolo-fused phenanthrolines

E Polo-Cuadrado, C Rojas-Peña, K Acosta-Quiroga… - RSC …, 2022 - pubs.rsc.org
Pyrazole-fused phenanthroline compounds were obtained through several synthetic routes.
NMR, HRMS, and IR techniques were used to characterize and confirm the chemical …

[HTML][HTML] Current strategies in design and synthesis of antifungals hybrid and chimeric diazine derivatives

D Diaconu, M Savu, C Ciobanu, V Mangalagiu… - Bioorganic & Medicinal …, 2025 - Elsevier
In the last decades fungal infections became a major threat to human health having an
unacceptably occurrence, a high rate of mortality and the number of patients at risk for these …