Cells have the ability to respond to various types of environmental cues, and in many cases
these cues induce directed cell migration towards or away from these signals. How cells …

Dendritic cells (DCs) are the key link between innate immunity and adaptive immunity and
play crucial roles in both the promotion of immune defense and the maintenance of immune …

Dendritic cells (DCs) are potent and versatile antigen-presenting cells, and their ability to
migrate is key for the initiation of protective pro-inflammatory as well as tolerogenic immune …

Leukocytes can completely reorganize their cytoskeletal architecture within minutes. This
structural plasticity, which facilitates their migration and communicative function, also …

The actin cytoskeleton and associated motor proteins provide the driving forces for
establishing the astonishing morphological diversity and dynamics of mammalian cells …

Phagocytosis, the regulated uptake of large particles (> 0.5 μm in diameter), is essential for
tissue homeostasis and is also an early, critical component of the innate immune response …

In eukaryotic cells, the nuclear envelope separates the genomic DNA from the cytoplasmic
space and regulates protein trafficking between the two compartments. This barrier is only …

Cell migration has two opposite faces: although necessary for physiological processes such
as immune responses, it can also have detrimental effects by enabling metastatic cells to …

RhoA is a ubiquitously expressed cytoplasmic protein that belongs to the family of small
GTPases. RhoA acts as a molecular switch that is activated in response to binding of …

Dendritic cells are at the center of immune responses. They are defined by their ability to
sense the environment, take up and process antigen, migrate to secondary lymphoid …