Depression in neurodegenerative diseases: Common mechanisms and current treatment options

CPC Galts, LEB Bettio, DC Jewett, CC Yang… - Neuroscience & …, 2019 - Elsevier
Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and a major
cause of disability worldwide. This neurological condition is commonly associated with …

Is dysregulation of the HPA-axis a core pathophysiology mediating co-morbid depression in neurodegenerative diseases?

X Du, TY Pang - Frontiers in psychiatry, 2015 - frontiersin.org
There is increasing evidence of prodromal manifestation of neuropsychiatric symptoms in a
variety of neurodegenerative diseases such as Parkinson's disease (PD) and Huntington's …

Systemic manifestation and contribution of peripheral tissues to Huntington's disease pathogenesis

CL Chuang, F Demontis - Ageing research reviews, 2021 - Elsevier
Huntington disease (HD) is an autosomal dominant neurodegenerative disease that is
caused by expansion of cytosine/adenosine/guanine repeats in the huntingtin (HTT) gene …

Environmental factors as modulators of neurodegeneration: Insights from gene–environment interactions in Huntington's disease

C Mo, AJ Hannan, T Renoir - Neuroscience & Biobehavioral Reviews, 2015 - Elsevier
Unlike many other neurodegenerative diseases with established gene–environment
interactions, Huntington's disease (HD) is viewed as a disorder governed by genetics. The …

Huntington's disease in the United States: variation by demographic and socioeconomic factors

E Bruzelius, J Scarpa, Y Zhao, S Basu… - Movement …, 2019 - Wiley Online Library
Background Despite extensive research regarding the etiology of Huntington's disease,
relatively little is known about the epidemiology of this rare disorder, particularly in the …

Unexpected role of physiological estrogen in acute stress-induced memory deficits

RE Hokenson, AK Short, Y Chen, AL Pham… - Journal of …, 2021 - Soc Neuroscience
Stress may promote emotional and cognitive disturbances, which differ by sex. Adverse
outcomes, including memory disturbances, are typically observed following chronic stress …

Chronic stress impairs the aquaporin-4-mediated glymphatic transport through glucocorticoid signaling

F Wei, J Song, C Zhang, J Lin, R Xue, LD Shan… - …, 2019 - Springer
Background The glymphatic system has recently been proposed to function as a brain-wide
macroscopic system for the clearance of potentially harmful molecules, such as amyloid beta …

Stress and Alzheimer's disease: A senescence link?

CE Lyons, A Bartolomucci - Neuroscience & biobehavioral reviews, 2020 - Elsevier
Chronic stress has been shown to promote numerous aging-related diseases, and to
accelerate the aging process itself. Of particular interest is the impact of stress on …

Stress and neurodegeneration

C Peña-Bautista, E Casas-Fernández, M Vento… - Clinica Chimica …, 2020 - Elsevier
Neurodegenerative diseases are a great concern because of aging worldwide population.
Despite substantial effort to advance our understanding of the etiology and potential …

Targeting psychologic stress signaling pathways in Alzheimer's disease

HS Futch, CL Croft, VQ Truong, EG Krause… - Molecular …, 2017 - Springer
Alzheimer's Disease (AD) is the most prevalent progressive neurodegenerative disease; to
date, no AD therapy has proven effective in delaying or preventing the disease course. In the …