Voltage-gated sodium channels initiate action potentials in nerve, skeletal muscle, and other
electrically excitable cells. Mutations in them cause a wide range of diseases. These …

By the introduction of technological advancement in methods of structural analysis,
electronics, and recombinant DNA techniques, research in physiology has become …

Ion channels are membrane proteins that act as gated pathways for the movement of ions
across cell membranes. They play essential roles in the physiology of all cells. In recent …

Familial disorders of skeletal muscle excitability were initially described early in the last
century and are now known to be caused by mutations of voltage-gated ion channels. The …

Structure and function of voltage-gated sodium channels - PMC Back to Top Skip to main
content NIH NLM Logo Access keys NCBI Homepage MyNCBI Homepage Main Content …

Voltage-gated sodium channels open (activate) when the membrane is depolarized and
close on repolarization (deactivate) but also on continuing depolarization by a process …

The Na V 1.4 sodium channel is highly expressed in skeletal muscle, where it carries almost
all of the inward Na+ current that generates the action potential, but is not present at …

The primary function of the presynaptic nerve terminal is to release transmitter quanta and
thus activate the postsynaptic target cell. In almost every step leading to the release of …

Mutations in α1A, the pore-forming subunit of P/Q-type calcium channels, are linked to
several human diseases, including familial hemiplegic migraine (FHM). We introduced the …

Slow inactivation in voltage-gated sodium channels is a biophysical process that governs
the availability of sodium channels over extended periods of time. Slow inactivation …