Mechanical loading is an important factor in musculoskeletal health and disease. Tendons
and ligaments require physiological levels of mechanical loading to develop and maintain …

Adult tendon tissue demonstrates a limited regenerative capacity, and the natural repair
process leaves fibrotic scar tissue with inferior mechanical properties. Surgical treatment is …

Recreating the extracellular matrix organization and cellular patterns of anisotropic tissues
in bioengineered constructs remains a significant biofabrication challenge. Magnetically …

Although the transcription factor EGR1 is known as NGF1-A, TIS8, Krox24, zif/268, and
ZENK, it still has many fewer names than biological functions. A broad range of signals …

Tendons are highly specialized load-bearing tissues with very limited healing capacity.
Given their mechanosensitive nature, the combination of tendon mimetic scaffolds with …

Tendons and ligaments are fibrous connective tissues vital to the transmission of force and
stabilization of the musculoskeletal system. Arising in precise regions of the embryo …

Due to the ability to differentiate into variety of cell types, mesenchymal stem cells (MSCs)
hold promise as source in cell-based therapy for treating injured tissue and degenerative …

Substantial challenges remain in constructing the native tendon-to-bone interface for rotator
cuff healing owing to the enthesis tissues' highly organized structural and compositional …

Background: The effects of fibroblast growth factor 2 (FGF-2) on healing after surgical repair
of chronic rotator cuff (RC) tears remain unclear. Hypothesis: FGF-2 enhances tenogenic …

For research on tendon injury, many different animal models are utilized; however, the
extent to which these species simulate the clinical condition and disease pathophysiology …