Inflammation and immunity in schizophrenia: implications for pathophysiology and treatment

GM Khandaker, L Cousins, J Deakin… - The Lancet …, 2015 - thelancet.com
Complex interactions between the immune system and the brain might have important
aetiological and therapeutic implications for neuropsychiatric brain disorders. A possible …

The P2X7 receptor in mood disorders: Emerging target in immunopsychiatry, from bench to bedside

IA von Mücke-Heim, JM Deussing - Neuropharmacology, 2023 - Elsevier
Psychiatric disorders are among the most burdensome disorders worldwide. Though
therapies have evolved over the last decades, treatment resistance still affects many …

Peripheral immune cell populations associated with cognitive deficits and negative symptoms of treatment-resistant schizophrenia

E Fernandez-Egea, PE Vertes, SM Flint, L Turner… - PloS one, 2016 - journals.plos.org
Background Hypothetically, psychotic disorders could be caused or conditioned by
immunological mechanisms. If so, one might expect there to be peripheral immune system …

Brain-immune crosstalk in the treatment of major depressive disorder

I Branchi, S Poggini, L Capuron, F Benedetti… - European …, 2021 - Elsevier
A growing number of studies are pointing out the need for a conceptual shift from a brain-
centered to a body-inclusive approach in mental health research. In this perspective, the link …

[HTML][HTML] Association between serum C-reactive protein and DSM-IV generalized anxiety disorder in adolescence: findings from the ALSPAC cohort

GM Khandaker, S Zammit, G Lewis, PB Jones - Neurobiology of stress, 2016 - Elsevier
Background Animal studies suggest a role of inflammation in the pathophysiology of anxiety,
but human studies of inflammatory markers and anxiety disorders are scarce. We report a …

[HTML][HTML] Persistent childhood and adolescent anxiety and risk for psychosis: a longitudinal birth cohort study

I Morales-Muñoz, ER Palmer, S Marwaha… - Biological …, 2022 - Elsevier
Background Persistent anxiety in childhood and adolescence could represent a novel
treatment target for psychosis, potentially targeting activation of stress pathways and …

Psychoneuroimmunology or immunopsychiatry?

CM Pariante - The Lancet Psychiatry, 2015 - thelancet.com
Comment 198 www. thelancet. com/psychiatry Vol 2 March 2015 that behaviour and
emotions are governed by peripheral immune mechanisms. You cannot cure yourself of a …

Inflammation and depression: A nervous plea for psychiatry to not become immune to interpretation

JP Konsman - Pharmaceuticals, 2019 - mdpi.com
The possibility that inflammation plays a causal role in major depression is an important
claim in the emerging field of immunopsychiatry and has generated hope for new …

Neuroscience, mental health and the immune system: overcoming the brain-mind-body trichotomy

CM Pariante - Epidemiology and psychiatric sciences, 2016 - cambridge.org
Psychiatry is having a great time. Over the last few years, we have seen an exceptional
explosion in neuroscience knowledge, and especially in our understanding of the molecular …

Brain free water alterations in first-episode psychosis: a longitudinal analysis of diagnosis, course of illness, and medication effects

JY Guo, TA Lesh, TA Niendam, JD Ragland… - Psychological …, 2021 - cambridge.org
BackgroundMultiple lines of evidence suggest the presence of altered neuroimmune
processes in patients with schizophrenia (Sz) and severe mood disorders. Recent studies …