In 1925, 5-methylcytosine was first reported in bacteria. However, its biological importance
was not intuitive for several decades. After this initial lag, the ubiquitous presence of this …

Although more studies are demonstrating that a father's environment can influence child
health and disease, the molecular mechanisms underlying non-genetic inheritance remain …

Previously, we discovered that ZFP57 is a maternal-zygotic effect gene, and it maintains
DNA methylation genomic imprint at multiple imprinted regions in mouse embryos. Despite …

Genomic imprinting, an epigenetic gene-marking phenomenon that occurs in the germline,
leads to parental-origin-specific expression of a small subset of genes in mammals …

In mammals, three major DNA methyltransferases, Dnmt1, Dnmt3a, and Dnmt3b, have been
identified. Dnmt3a and Dnmt3b are responsible for establishing DNA methylation patterns …

DNMT1 is the main enzyme that uses the information on DNA methylation patterns in the
parent strand and methylates the daughter strand in freshly replicated hemimethylated DNA …

Background Thousands of mammalian promoters are defined by co-enrichment of the
histone tail modifications H3K27me3 (repressive) and H3K4me3 (activating) and are thus …

DNA methylation is an essential epigenetic mark in mammals. The proper distribution of this
mark depends on accurate deposition and maintenance mechanisms, and underpins its …

Developmental arsenic exposure has been associated with cognitive deficits in
epidemiological studies, but the underlying mechanisms remain poorly understood. Here …

The maintenance of key germline derived DNA methylation patterns during preimplantation
development depends on stores of DNA cytosine methyltransferase-1o (DNMT1o) provided …