Lentiviral vectors have been successfully used in the clinic and they are increasingly being
used for nonclinical applications. They are capable of stably transducing a broad range of …

Despite being at the origin of one of the world's most devastating public health concerns, the
Human Immunodeficiency Virus (HIV) has properties that can be harnessed for therapeutic …

Insertional oncogene activation and aberrant splicing have proved to be major setbacks for
retroviral stem cell gene therapy. Integrase-deficient human immunodeficiency virus-1 …

The treatment of a number of diseases can be achieved through gene addition therapy,
where curative transgenes are established within the patient's cells after delivery with viral or …

Introduction: The development of new strategies for the induction of potent and broad
immune responses is of high priority in the vaccine field. In this setting, integrase-defective …

Plasmids are circular or linear DNA molecules propagated extra-chromosomally in bacteria.
Evolution shaped plasmids are inherently mosaic structures with individual functional units …

Integration-defective lentiviral vectors (IDLVs) have become an important alternative tool for
gene therapy applications and basic research. Unfortunately, IDLVs show lower transgene …

Gene therapy relies on the delivery of therapeutic genes into patients' cells. The
microdevices used to reach the cells and to transfer the gene payload are called gene …

Gene transfer allows transient or permanent genetic modifications of cells for experimental
or therapeutic purposes. Gene delivery by HIV-derived lentiviral vector (LV) is highly …

Improved health span and lifespan extension in a wide phylogenetic range of species is
associated with the induction of the environmental cell stress response through a signalling …