The work reports the results of an analysis of the lidocaine molecule conformational
behavior in a supercritical carbon dioxide medium. Based on the nuclear Overhauser effect …

The search for new forms of already known drug compounds is an urgent problem of high
relevance as more potent drugs with fewer side effects are needed. The trifluoromethyl …

In this work, we studied the equilibrium between lidocaine conformers with an intramolecular
hydrogen bond and those without such bond in a diluted lidocaine solution in scCO 2 (with …

This work presents an analysis of the lidocaine spatial structure in SC-CO2. Two-
dimensional nuclear Overhauser effect spectroscopy (2D NOESY) and quantum chemical …

It is well-established that the occurrence of solution-mediated phase transformation makes
the precise preparation of pure metastable forms of drugs by solution crystallization methods …

In this work, we study conformational equilibria of lidocaine molecules in a saturated
lidocaine solution in scCO 2 under heating conditions in the temperature range of 35–80° C …

In this work, we studied conformational equilibria of molecules of lidocaine in its highly
concentrated solutions in scCO 2 at the CO 2 density values ranging from∼ 1.5 to∼ 2.0 of …

In this paper we present the results of polymethylmethacrylate (PMMA) impregnation with
carbamazepine (CBZ) in a supercritical carbon dioxide (scCO 2) medium at two different …

Supercritical carbon dioxide (scCO2) plays an essential role in various technological
procedures, making the solubility of drugs in scCO2 a crucial aspect of the drug formulation …

In this work, we studied the conformational equilibria of lidocaine molecules released from
NCC-based aerogel that was preliminarily impregnated with lidocaine. The doping of the …