Molecular and evolutionary processes generating variation in gene expression
Heritable variation in gene expression is common within and between species. This
variation arises from mutations that alter the form or function of molecular gene regulatory …
variation arises from mutations that alter the form or function of molecular gene regulatory …
Structural insights into nuclear transcription by eukaryotic DNA-dependent RNA polymerases
The eukaryotic transcription apparatus synthesizes a staggering diversity of RNA molecules.
The labour of nuclear gene transcription is, therefore, divided among multiple DNA …
The labour of nuclear gene transcription is, therefore, divided among multiple DNA …
A high-resolution protein architecture of the budding yeast genome
The genome-wide architecture of chromatin-associated proteins that maintains chromosome
integrity and gene regulation is not well defined. Here we use chromatin …
integrity and gene regulation is not well defined. Here we use chromatin …
[HTML][HTML] “Structure”-function relationships in eukaryotic transcription factors: the role of intrinsically disordered regions in gene regulation
Many principles of bacterial gene regulation have been foundational to understanding
mechanisms of eukaryotic transcription. However, stark structural and functional differences …
mechanisms of eukaryotic transcription. However, stark structural and functional differences …
The code and beyond: transcription regulation by the RNA polymerase II carboxy-terminal domain
KM Harlen, LS Churchman - Nature reviews Molecular cell biology, 2017 - nature.com
The carboxy-terminal domain (CTD) extends from the largest subunit of RNA polymerase II
(Pol II) as a long, repetitive and largely unstructured polypeptide chain. Throughout the …
(Pol II) as a long, repetitive and largely unstructured polypeptide chain. Throughout the …
Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae
M Conrad, J Schothorst, HN Kankipati… - FEMS microbiology …, 2014 - academic.oup.com
The yeast Saccharomyces cerevisiae has been a favorite organism for pioneering studies
on nutrient-sensing and signaling mechanisms. Many specific nutrient responses have been …
on nutrient-sensing and signaling mechanisms. Many specific nutrient responses have been …
Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator
AL Sanborn, BT Yeh, JT Feigerle, CV Hao… - Elife, 2021 - elifesciences.org
Gene activator proteins comprise distinct DNA-binding and transcriptional activation
domains (ADs). Because few ADs have been described, we tested domains tiling all yeast …
domains (ADs). Because few ADs have been described, we tested domains tiling all yeast …
Structures of transcription preinitiation complex engaged with the+ 1 nucleosome
The preinitiation complex (PIC) assembles on promoters of protein-coding genes to position
RNA polymerase II (Pol II) for transcription initiation. Previous structural studies revealed the …
RNA polymerase II (Pol II) for transcription initiation. Previous structural studies revealed the …
Structural biology of RNA polymerase II transcription: 20 years on
S Osman, P Cramer - Annual Review of Cell and …, 2020 - annualreviews.org
Gene transcription by RNA polymerase II (Pol II) is the first step in the expression of the
eukaryotic genome and a focal point for cellular regulation during development …
eukaryotic genome and a focal point for cellular regulation during development …
Architecture of the RNA polymerase II–Mediator core initiation complex
C Plaschka, L Lariviere, L Wenzeck, M Seizl… - Nature, 2015 - nature.com
The conserved co-activator complex Mediator enables regulated transcription initiation by
RNA polymerase (Pol) II. Here we reconstitute an active 15-subunit core Mediator (cMed) …
RNA polymerase (Pol) II. Here we reconstitute an active 15-subunit core Mediator (cMed) …