Voltage-gated sodium ion channel subtype 1.7 (NaV1. 7) is a high interest target for the
discovery of non-opioid analgesics. Compelling evidence from human genetic data …

The production of fully functional insulin-secreting cells to treat diabetes is a major goal of
regenerative medicine. In this article, I review progress towards this goal over the last 15 …

Computational drug repositioning requires assessment of the functional similarities among
compounds. Here, we report a new method for measuring compound functional similarity …

Abstract Aims/hypothesis Bisphenol-A (BPA) is a widespread endocrine-disrupting chemical
that has been associated with type 2 diabetes development. Low doses of BPA modify …

Aims/hypothesis Recovering functional beta cell mass is a promising approach for future
diabetes therapies. The aim of the present study is to investigate the effects of adjudin, a …

Pancreatic beta cells, unique cells that secrete insulin in response to an increase in glucose
levels, play a significant role in glucose homeostasis. Glucose-stimulated insulin secretion …

The present study was undertaken to determine the involvement of voltage-gated Na+
channel (VGSC) and other mechanism related to insulin secretion in polysaccharides from …

Voltage-gated sodium channels (NaV) are pivotal proteins responsible for initiating and
transmitting action potentials. Emerging evidence suggests that proteolytic cleavage of …

Diabetes mellitus (DM) is a common chronic medical problem worldwide; one of its
complications is painful peripheral neuropathy, which can substantially erode quality of life …

Pancreatic β cell dysfunction is a central component of diabetes progression. During the last
decades, the genetic basis of several monogenic forms of diabetes has been recognized …