Inflammation has been reported to be intimately linked to the development or worsening of
several non-infectious diseases. A number of chronic conditions such as cancer, diabetes …

Monocytes are circulating blood leukocytes that play important roles in the inflammatory
response, which is essential for the innate response to pathogens. But inflammation and …

Dendritic cells (DCs) represent a small and heterogeneous fraction of the hematopoietic
system, specialized in antigen capture, processing, and presentation. The different DC …

Monocytes can have important effects on the polarization and expansion of lymphocytes and
may contribute to shaping primary and memory T‐cell responses in humans and mice …

Engagement of the T cell receptor complex reprograms T cells for proliferation, cytokine
production and differentiation towards effector cells. This process depends on activating …

Background Excessive activity of dendritic cells (DCs) is postulated as a central disease
mechanism in Systemic Lupus Erythematosus (SLE). Vitamin D is known to reduce …

Langerhans cells (LCs) in epithelia and interstitial dendritic cells (intDCs) in adjacent
connective tissues represent two closely related myeloid-derived DC subsets that exert …

NF-κB inducing kinase (NIK) is required for osteoclastogenesis in response to pathologic
stimuli, and its loss leads to functional blockade of both alternative and classical NF-κB …

Monocytes serve as a central defense system against infection and injury but can also
promote pathological inflammatory responses. Considering the evidence that monocytes …

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