Genetic background and molecular mechanisms of juvenile idiopathic arthritis

S La Bella, M Rinaldi, A Di Ludovico… - International Journal of …, 2023 - mdpi.com
Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in the
paediatric population. JIA comprises a heterogeneous group of disorders with different onset …

Distinct molecular and immune hallmarks of inflammatory arthritis induced by immune checkpoint inhibitors for cancer therapy

ST Kim, Y Chu, M Misoi, ME Suarez-Almazor… - Nature …, 2022 - nature.com
Immune checkpoint inhibitors are associated with immune-related adverse events (irAEs),
including arthritis (arthritis-irAE). Management of arthritis-irAE is challenging because …

CD4+ T-Cell Plasticity in Non-Infectious Retinal Inflammatory Disease

YH Chen, S Lightman, VL Calder - International Journal of Molecular …, 2021 - mdpi.com
Non-infectious uveitis (NIU) is a potentially sight-threatening disease. Effector CD4+ T cells,
especially interferon-γ-(IFNγ) producing Th1 cells and interleukin-17-(IL-17) producing Th17 …

[HTML][HTML] Th1 polarization defines the synovial fluid T cell compartment in oligoarticular juvenile idiopathic arthritis

AM Julé, KJ Hoyt, K Wei, M Gutierrez-Arcelus… - JCI insight, 2021 - ncbi.nlm.nih.gov
Oligoarticular juvenile idiopathic arthritis (oligo JIA) is the most common form of chronic
inflammatory arthritis in children, yet the cause of this disease remains unknown. To …

Identification of novel molecular markers of human Th17 cells

A Sałkowska, K Karaś, I Karwaciak… - Cells, 2020 - mdpi.com
Th17 cells are important players in host defense against pathogens such as Staphylococcus
aureus, Candida albicans, and Bacillus anthracis. Th17 cell-mediated inflammation, under …

Signals and mechanisms regulating monocyte and macrophage activation in the pathogenesis of juvenile idiopathic arthritis

CY Wu, HY Yang, JL Huang, JH Lai - International journal of molecular …, 2021 - mdpi.com
Monocytes (Mos) and macrophages (Mφs) are key players in the innate immune system and
are critical in coordinating the initiation, expansion, and regression of many autoimmune …

Human regulatory T cells locally differentiate and are functionally heterogeneous within the inflamed arthritic joint

L Lutter, MM van der Wal, EC Brand… - Clinical & …, 2022 - Wiley Online Library
Objective Tregs are crucial for immune regulation, and environment‐driven adaptation of
effector (e) Tregs is essential for local functioning. However, the extent of human Treg …

[HTML][HTML] Efficacy and safety of total glucosides of paeony in the treatment of 5 types of inflammatory arthritis: A systematic review and meta-analysis

K Yang, L Zeng, Z Long, Q He, W Xiang, A Ge… - Pharmacological …, 2023 - Elsevier
Objective To evaluate efficacy and safety of total glucosides of paeony in the treatment of 5
types of inflammatory arthritis Methods Databases such as Pubmed, Cochran Library …

Current and emerging biologics for the treatment of juvenile idiopathic arthritis

R Cimaz, G Maioli, G Calabrese - Expert opinion on biological …, 2020 - Taylor & Francis
Introduction The management of a child with juvenile idiopathic arthritis (JIA) requires a
combination of pharmacological, physical, and psychosocial therapies in order to induce …

Clonally expanded PD‐1‐expressing T cells are enriched in synovial fluid of juvenile idiopathic arthritis patients

A Vanni, A Mazzoni, R Semeraro… - European journal of …, 2023 - Wiley Online Library
Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic condition in
childhood. The disease etiology remains largely unknown; however, a key role in JIA …