Autophagy in Parkinson's disease
Impaired protein homeostasis and accumulation of damaged or abnormally modified protein
are common disease mechanisms in many neurodegenerative disorders, including …
are common disease mechanisms in many neurodegenerative disorders, including …
Targeting autophagy, oxidative stress, and ER stress for neurodegenerative disease treatment
Protein homeostasis is a vital process for cell function and, therefore, disruption of the
molecular mechanisms involved in this process, such as autophagy, may contribute to …
molecular mechanisms involved in this process, such as autophagy, may contribute to …
The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration
AL Mahul-Mellier, J Burtscher… - Proceedings of the …, 2020 - National Acad Sciences
Parkinson's disease (PD) is characterized by the accumulation of misfolded and aggregated
α-synuclein (α-syn) into intraneuronal inclusions named Lewy bodies (LBs). Although it is …
α-synuclein (α-syn) into intraneuronal inclusions named Lewy bodies (LBs). Although it is …
Mitophagy in Alzheimer's disease and other age-related neurodegenerative diseases
Mitochondrial dysfunction is a central aspect of aging and neurodegenerative diseases,
including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and …
including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and …
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …
Since then, this topic has received increasing attention, and many scientists have entered …
The RING finger protein family in health and disease
C Cai, YD Tang, J Zhai, C Zheng - Signal transduction and targeted …, 2022 - nature.com
Ubiquitination is a highly conserved and fundamental posttranslational modification (PTM) in
all eukaryotes regulating thousands of proteins. The RING (really interesting new gene) …
all eukaryotes regulating thousands of proteins. The RING (really interesting new gene) …
Oxidative stress, mitochondrial dysfunction, and aging
H Cui, Y Kong, H Zhang - Journal of signal transduction, 2012 - Wiley Online Library
Aging is an intricate phenomenon characterized by progressive decline in physiological
functions and increase in mortality that is often accompanied by many pathological …
functions and increase in mortality that is often accompanied by many pathological …
Interplay of LRRK2 with chaperone-mediated autophagy
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial
Parkinson's disease. We found LRRK2 to be degraded in lysosomes by chaperone …
Parkinson's disease. We found LRRK2 to be degraded in lysosomes by chaperone …
The mitochondrial transcription factor TFAM in neurodegeneration: emerging evidence and mechanisms
The mitochondrial transcription factor A, or TFAM, is a mitochondrial DNA (mt DNA)‐binding
protein essential for genome maintenance. TFAM functions in determining the abundance of …
protein essential for genome maintenance. TFAM functions in determining the abundance of …
Mitophagy in Parkinson's disease: from pathogenesis to treatment
J Liu, W Liu, R Li, H Yang - Cells, 2019 - mdpi.com
Parkinson's disease (PD) is the second most common neurodegenerative disease. The
pathogenesis of PD is complicated and remains obscure, but growing evidence suggests …
pathogenesis of PD is complicated and remains obscure, but growing evidence suggests …