Mechanotransduction is pivotal in the maintenance of homeostasis in different tissues and
involves multiple cell signaling pathways. In bone, mechanical stimuli regulate the balance …

Cranial sutures are dynamic structures in which stem cell biology, bone formation, and
mechanical forces interface, influencing the shape of the skull throughout development and …

Pivotal in many ways for human health, the control of adult bone mass is governed by
complex, incompletely understood crosstalk namely between mesenchymal stem cells …

Mechanical loading is a key factor governing bone adaptation. Both preclinical and clinical
studies have demonstrated its effects on bone tissue, which were also notably predicted in …

Type 1 diabetes (T1D) is one of the most common chronic diseases in childhood, with a
progressively increasing incidence. T1D management requires lifelong insulin treatment …

Though gait asymmetry is used as a metric of functional recovery in clinical rehabilitation,
there is no consensus on an ideal method for its evaluation. Various methods have been …

Reducing the musculoskeletal deterioration that astronauts experience in microgravity
requires countermeasures that can improve the effectiveness of otherwise rigorous and time …

Axial loading in rodents provides a controlled setting for mechanical loading, because load
and subsequent strain, frequency, number of cycles and rest insertion between cycles, are …

Bone continually adapts to changing external loading conditions via (re) modeling
(modeling and remodeling) processes. While physical activity is known to beneficially …

It has been known that moderate mechanical loading, like that caused by exercise, promotes
bone formation. However, its underlying mechanisms remain elusive. Here we showed that …