Purinergic signalling: therapeutic developments

G Burnstock - Frontiers in pharmacology, 2017 - frontiersin.org
Purinergic signalling, ie, the role of nucleotides as extracellular signalling molecules, was
proposed in 1972. However, this concept was not well accepted until the early 1990's when …

Effects of diabetes on microglial physiology: a systematic review of in vitro, preclinical and clinical studies

M Vargas-Soria, M García-Alloza… - Journal of …, 2023 - Springer
Diabetes mellitus is a heterogeneous chronic metabolic disorder characterized by the
presence of hyperglycemia, commonly preceded by a prediabetic state. The excess of blood …

Silver nanoparticles-decorated Preyssler functionalized cellulose biocomposite as a novel and efficient catalyst for the synthesis of 2-amino-4H-pyrans and …

S Saneinezhad, L Mohammadi, V Zadsirjan… - Scientific reports, 2020 - nature.com
Silver nanoparticles-decorated Preyssler functionalized cellulose biocomposite (PC/AgNPs)
was prepared and fully characterized by FTIR, UV–vis, SEM, and TEM techniques. The …

Retinal microglia–A key player in healthy and diseased retina

G Rathnasamy, WS Foulds, EA Ling, C Kaur - Progress in neurobiology, 2019 - Elsevier
Microglia, the resident immune cells of the brain and retina, are constantly engaged in the
surveillance of their surrounding neural tissue. During embryonic development they infiltrate …

The pathophysiology of retinopathy of prematurity: an update of previous and recent knowledge

G Cavallaro, L Filippi, P Bagnoli… - Acta …, 2014 - Wiley Online Library
Retinopathy of prematurity (ROP) is a disease that can cause blindness in very low
birthweight infants. The incidence of ROP is closely correlated with the weight and the …

Adenosine signalling in diabetes mellitus—pathophysiology and therapeutic considerations

L Antonioli, C Blandizzi, B Csóka, P Pacher… - Nature reviews …, 2015 - nature.com
Adenosine is a key extracellular signalling molecule that regulates several aspects of tissue
function by activating four G-protein-coupled receptors, A1, A2A, A2B and A1 adenosine …

The role of microglia in diabetic retinopathy

JG Grigsby, SM Cardona, CE Pouw… - Journal of …, 2014 - Wiley Online Library
There is growing evidence that chronic inflammation plays a role in both the development
and progression of diabetic retinopathy. There is also evidence that molecules produced as …

Metabolic dysregulation and neurovascular dysfunction in diabetic retinopathy

T Yumnamcha, M Guerra, LP Singh, AS Ibrahim - Antioxidants, 2020 - mdpi.com
Diabetic retinopathy is a major cause of ocular complications in patients with type 1 and type
2 diabetes in developed countries. Due to the continued increase in the number of people …

Anti-inflammatory therapy for diabetic retinopathy

W Zhang, H Liu, M Rojas, RW Caldwell… - Immunotherapy, 2011 - Taylor & Francis
Diabetic retinopathy (DR) is one of the most common complications of diabetes. This
devastating disease is a leading cause of blindness in people of working age in …

Smart nano-micro platforms for ophthalmological applications: The state-of-the-art and future perspectives

Q Lyu, L Peng, X Hong, T Fan, J Li, Y Cui, H Zhang… - Biomaterials, 2021 - Elsevier
Smart nano-micro platforms have been extensively applied for diverse biomedical
applications, mostly focusing on cancer therapy. In comparison with conventional …