Vitamins are dietary components which are necessary for life. They play a major role in health and their deficiency may be linked to symptoms of psychiatric disorders. B vitamins …
Accurate prediction of standard binding free energies describing protein–ligand association remains a daunting computational endeavor. This challenge is rooted to a large extent in the …
Recent studies at the nanometer scale have revealed that relatively uniform clusters of adhesion proteins (50–100 nm) constitute the modular units of cell adhesion sites in both …
LA Lane - Applied Physics Reviews, 2020 - pubs.aip.org
Nanomedicine aims to increase the effectiveness of therapeutic and diagnostic agents by exploiting unique properties that arise when operating at the nanoscale. Despite the recent …
C Jurchenko, Y Chang, Y Narui, Y Zhang, KS Salaita - Biophysical journal, 2014 - cell.com
The interplay between chemical and mechanical signals plays an important role in cell biology, and integrin receptors are the primary molecules involved in sensing and …
Stimuli-responsive macromolecular assemblies are of great interest in drug delivery applications, as it holds the promise to keep the drug molecules sequestered under one set …
The high affinity (KD~ 10− 15 M) of biotin for avidin and streptavidin is the essential component in a multitude of bioassays with many experiments using biotin modifications to …
The protein–ligand binding affinity quantifies the binding strength between a protein and its ligand. Computer modeling and simulations can be used to estimate the binding affinity or …
An electrostatically embedded generalized molecular fractionation with conjugate caps (EE- GMFCC) method (J. Phys. Chem. A, 2013, 117, 7149) has been successfully used for …