The α7-type nicotinic acetylcholine receptor is one of the most unique and interesting of all
the members of the cys-loop superfamily of ligand-gated ion channels. Since it was first …

Amino-pyrazoles have proven to be a class of fascinating and privileged organic tools for the
construction of diverse heterocyclic or fused heterocyclic scaffolds. This review presents …

Dementia represents a major problem of health and disability, with a relevant economic
impact on our society. Despite important advances in pathogenesis, diagnosis and …

Human α7 nicotinic acetylcholine receptor (nAChR) is a promising therapeutic target for the
treatment of schizophrenia accompanied with cognitive impairment. Herein, we report the …

Four 3-((hetera) cyclobutyl) azetidine-based isosteres of piperidine, piperazine, and
morpholine were designed and synthesized on up to gram scale. The key step of the …

Two sulfonamides derivatives, N-phenethyl-4-methylbenzenesulfonamide (1) and N-(4-
hydroxyphenethyl)-4-methylbenzenesulfonamide (2), were successfully synthesized and …

Despite intensive efforts, no inhibitors of the Wnt/β-catenin signaling pathway have been
approved so far for the clinical treatment of cancer. We synthesized novel N …

We report here the synthesis of a large library of 1, 2, 3-triazole derivatives which were in
vitro tested as α7 nAchR ligands. The SAR study revealed that several crucial factors are …

JMJD6 is a member of the JmjC domain-containing family and has been identified as a
promising therapeutic target for treating estrogen-induced and triple-negative breast cancer …

Homomeric α7 nicotinic acetylcholine receptors (nAChRs) are implicated in the regulation of
cognitive processes such as memory and attention and have potential as therapeutic targets …